{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:53:03Z","timestamp":1768787583635,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9331,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Creatine kinase BB has been described to be elevated in the serum of patients with prostate cancer. The incidence of abnormal serum levels correlates with the degree of differentiation of the tumor; that is, the more poorly differentiated tumors are associated most frequently with elevated CK\u2010BB levels. We have recently described two additional findings which involve CK\u2010BB in prostate cancer: 1) the finding of abnormally migrating CK\u2010BB bands reported to be IgG\u2010CK\u2010BB complexes in several Stage D patients and in 2\/3 Stage B patients following <jats:sup>125<\/jats:sup>I implants, and 2) significant differences between CK\u2010BB purified from prostatic fluid from CK\u2010BB of brain origin. In particular, we find two bands of prostatic CK\u2010BB following purification as compared to a single band from brain, when the same purification protocol is used. While further characterization of these differences is proceeding, the two bands of CK\u2010BB are being used to develop a prostate\u2010specific antiserum for use in immunoassays to detect prostate cancer in conjunction with other traditional markers such as prostatic acid phosphatase. If serum detection of tumor markers is to be efficacious, tumor marker panels such as CK\u2010BB and prostatic acid phosphatase may provide a significant advantage over individual markers.<\/jats:p>","DOI":"10.1002\/pros.2990020111","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:38:34Z","timestamp":1172014714000},"page":"109-119","source":"Crossref","is-referenced-by-count":17,"title":["Creatine kinase BB and other markers of prostatic carcinoma"],"prefix":"10.1002","volume":"2","author":[{"given":"Lawrence M.","family":"Silverman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcie E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald B.","family":"Dermer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus","family":"Pullano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u0227n A.","family":"T\u00f6kes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(72)90085-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/clinchem\/26.7.861","article-title":"Creatine kinase radioimmunoassay and isoenzyme electrophoresis compared in the diagnosis of acute myocardial infarction","volume":"26","author":"Homburger HA","year":"1980","journal-title":"Clin Chem"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/clinchem\/25.8.1432","article-title":"Creatine kinase BB : A new tumor\u2010associated marker","volume":"25","author":"Silverman LM","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/clinchem\/26.1.55","article-title":"Circulating CK\u2010MB and CK\u2010BB isoenzymes after prostate resection","volume":"26","author":"Kimler SC","year":"1980","journal-title":"Clin Chem"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/clinchem\/25.3.461","article-title":"Macro creatine kinase BB in serum, and some data on its prevalence","volume":"25","author":"Urdal P","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90091-9"},{"key":"e_1_2_1_8_2","first-page":"113","article-title":"Immunoperoxidase technique","volume":"102","author":"Taylor CR","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/S0021-9258(17)40357-7","article-title":"Brain isoenzyme of creatine kinase. II. Species specificity of enzyme and presence of inactive form in striated muscle of rabbit and man","volume":"252","author":"Armstrong JB","year":"1977","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0022-5347(17)67171-4","article-title":"Isolation and identification of the human malignant prostatic epithelial cell in pure monolayer culture","volume":"114","author":"Stonington OG","year":"1975","journal-title":"J Urol"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990020111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990020111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:39:40Z","timestamp":1699767580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990020111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/pros.2990020111"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990020111","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}