{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:33:02Z","timestamp":1758814382098},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From September, 1978, to November, 1980, 69 consecutive patients with locally advanced (T<jats:sub>3<\/jats:sub>\u2010T<jats:sub>4<\/jats:sub>) prostatic adenocarcinoma, with or without distant metastases, were treated with oral estramustine phosphate. Dosage was 15 mg\/kg\/day for 2 months, followed by 5 mg\/kg\/day until progression. In the 48 evaluable patients with progressive disease at entry in the study, 1 complete response, 7 partial responses, 31 disease stabilizations, and 9 progressions were encountered (81.2% NPCP response rate). Karnofsky performance status equal to or less than 50 was predictive of poor response to estramustine phosphate.<\/jats:p><jats:p>In the 10 evaluable patients with stabilized disease at entry in the study after orchiectomy, 2 complete responses, 4 partial responses, 3 disease stabilization, and 1 progression were noted.<\/jats:p><jats:p>The major side effects observed were gynecomastia, nausea, and vomiting.<\/jats:p>","DOI":"10.1002\/pros.2990030208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:46:59Z","timestamp":1172015219000},"page":"159-164","source":"Crossref","is-referenced-by-count":10,"title":["Estramustine phosphate (estracyt\u00ae) treatment of T<sub>3<\/sub>\u2013T<sub>4<\/sub> prostatic carcinoma"],"prefix":"10.1002","volume":"3","author":[{"given":"Andrea","family":"Veronesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiberto","family":"Zattoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Frustaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Galligioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Trov\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Tumolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Artuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cosciani\u2010Cunico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eligio","family":"Grigoletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365597709179957"},{"key":"e_1_2_1_3_2","first-page":"229","article-title":"Clinical results with Estramustine Phosphate, (nSC 89\u2013199): a comparison of the intravenous and oral preparation","volume":"59","author":"Nilsson T","year":"1975","journal-title":"Cancer Chem Rep"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)59220-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-5347(17)58499-2","article-title":"Estramustine Phosphate: a specific chemotherapeutic agent?","volume":"117","author":"Von Hoff DD","year":"1977","journal-title":"J Urol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-5-681"},{"key":"e_1_2_1_7_2","first-page":"219","article-title":"Oral Estramustine Phosphate (sNC 89\u2013199) in the treatment of advanced (stage D) carcinoma of the prostate","volume":"59","author":"Mittelman A","year":"1975","journal-title":"Cancer Chemother 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