{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:39:59Z","timestamp":1697780399097},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8601,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution in the prostate of norfloxacin and rosoxacin, both quinoline carboxylic acid derivatives, was investigated in an experimental dog model. The concentrations in prostatic interstitial fluid (PIF) and prostatic secretion (PS) of both antimicrobials were lower than the corresponding plasma (P) concentrations, as might be expected for acidic compounds. Norfloxacin achieved significantly higher PS\/P and PIF\/P ratios than rosoxacin following intravenous infusion; there were no differences between the two drugs in the various tissue\/plasma ratios. The concentrations of both norfloxacin and rosoxacin in PIF, PS, and urine were in the minimal inhibitory range for most gram\u2010negative pathogens causing bacterial prostatitis and urinary tract infections. Clinical trials may be warranted for both drugs.<\/jats:p>","DOI":"10.1002\/pros.2990040411","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:10:47Z","timestamp":1172016647000},"page":"407-414","source":"Crossref","is-referenced-by-count":4,"title":["Distribution of quinoline carboxylic acid derivatives in the dog prostate"],"prefix":"10.1002","volume":"4","author":[{"given":"Klaus M.\u2010E.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul O.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.2.103"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.19.1.188"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.4.670"},{"key":"e_1_2_1_5_2","first-page":"49","article-title":"Comparison of the antimicrobial activity of norfloxacin (MK 0366, AM 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents","volume":"10","author":"Gadebush HH","year":"1982","journal-title":"Infection"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.4.604"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.1.23"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.20.2.265"},{"key":"e_1_2_1_9_2","volume-title":"Investigators Brochure","author":"Merck, Sharp and Dohme Research Laboratories","year":"1980"},{"key":"e_1_2_1_10_2","unstructured":"DrylieDM: Comparison of cinoxacin and nalidixic acid in the treatment of urinary tract infections. In Siegenthaler W Luthy R (eds) \u201cCurrent Chemotherapy \u201d Vol 1. Proceedings of the 10th International Congress of Chemotherapy 1977\u20131977 pp700\u2013702."},{"key":"e_1_2_1_11_2","unstructured":"KlasterkyJ Kahan\u2010CoppensL: Comparative study of cinoxacin and cotrimoxazole in complicated urinary tract infections: A double\u2010blind randomized study. In Siegenthaler W Luthy R (eds): \u201cCurrent Chemotherapy \u201d Vol 1. Proceedings of the 10th International Congress of Chemotherapy 1977 pp702\u2013704."},{"key":"e_1_2_1_12_2","unstructured":"LindanR: Comparison of cinoxacin and introfurantoin in the treatment of urinary infections in geriatric patients. In Siegenthaler W Luthy R (eds): \u201cCurrent Chemotherapy \u201d Vol 1. Proceedings of the 10th International Congress of Chemotherapy 1977 pp704\u2013705."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(77)90157-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-5347(17)55828-0","article-title":"Prostatitis syndromes: New perspectives about old woes","volume":"123","author":"Meares EM","journal-title":"J Urol"},{"key":"e_1_2_1_15_2","first-page":"149","article-title":"Rosoxacin and cinoxacin distribution in prostate, vagina and female urethra. An experimental study in dogs","volume":"17","author":"Maigaard S","year":"1979","journal-title":"Invest Urol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61919-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00263738"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)57333-4"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990040411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990040411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T14:42:44Z","timestamp":1697726564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990040411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/pros.2990040411"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990040411","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}