{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:16:17Z","timestamp":1759961777292},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":7870,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism of the observed synergistic effect of prolactin and androgen on the lateral lobe of the rat prostate is not established. The observation that prolactin alone delayed the rate of loss of weight, protein, and DNA of the lateral lobe in castrated rats has led us to question the assumption that the effect of prolactin is produced by a modification of recognized androgen\u2010induced intracellular changes. The present study was conducted to explore whether or not the sites of prolactin action in the rat prostate coincided with those recognized as the androgen effect. Two anterior pituitaries from female donors were grafted under the right renal capsule of adult male Sprague\u2010Dawley rats. Seven days later, bilateral orchiectomy and unilateral nephrectomy were performed in these rats. In one half of the animals, the kidney bearing the pituitary grafts was removed. In the other half, the contralateral kidney was removed. Seven days following the orchiectomy\u2010nephrectomy, animals bearing the pituitary grafts had a higher level of serum prolactin (93 \u00b1 7 ng\/ml, mean \u00b1 SE) than in those without the graft (26 \u00b1 3 ng\/ml). This condition of hyperprolactinemia was associated with the delay of castration\u2010induced regression in the lateral prostate. The rate of protein degradation, as judged by the amount of radioactivity remaining in the tissue following a single i.v. pulse of <jats:sup>3<\/jats:sup>H\u2010leucine 24 hr before orchiectomy\u2010nephrectomy, was significantly slower in the lateral prostate in graft\u2010bearing animals than in those without grafts. However, the rate of protein synthesis, as judged by both in vitro and in vivo incorporation of <jats:sup>3<\/jats:sup>H\u2010leucine into the protein fractions of the prostate, was not significantly different between the two groups. Nor was the total activity of cathepsin D in the lateral prostate different. These results were not consistent with parameters known as the effect mediated through androgen\u2010controlled mechanisms. We therefore conclude that the action of prolactin in the regressing rat prostate is probably not mediated through the action of androgen.<\/jats:p>","DOI":"10.1002\/pros.2990060107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:43:05Z","timestamp":1172018585000},"page":"49-59","source":"Crossref","is-referenced-by-count":25,"title":["Metabolic action of prolactin in regressing prostate: Independent of androgen action"],"prefix":"10.1002","volume":"6","author":[{"given":"Cornelius","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Assimos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Grayhack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53916-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolreprod\/22.2.351"},{"key":"e_1_2_1_4_2","first-page":"20","article-title":"Effect of prolactin on the metabolism of androgens by the rat ventral prostate gland in vitro","volume":"14","author":"Manandhar MSP","year":"1976","journal-title":"Invest Urol"},{"key":"e_1_2_1_5_2","first-page":"854","article-title":"Effect of prolactin, growth hormone and insulin in uptake and binding of dihydrotes\u2010tosterone in the cultured rat ventral prostate","volume":"81","author":"Johansson R","year":"1976","journal-title":"Acta Endocrinol"},{"key":"e_1_2_1_6_2","unstructured":"AssimosD SmithC LeeC GrayhackJT: Failure of Flutamide to block the effect of prolactin on delay of castration\u2010induced regression in rat prostate.The Prostate(submitted)."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60962-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1700115"},{"key":"e_1_2_1_9_2","first-page":"169","article-title":"Incorporation and release of tritiated leucine in rat prostate during castration\u2010induced involution","volume":"19","author":"Bockrath JM","year":"1981","journal-title":"Invest Urol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5347(17)54059-8","article-title":"Activities of cathepsin D in rat prostate during castration\u2010induced involution","volume":"127","author":"Tanabe ET","year":"1982","journal-title":"J Urol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990030111"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-95-6-1754"},{"key":"e_1_2_1_13_2","first-page":"3301","article-title":"Alternate fluctuations of leucine and thymidine incorporation by mammary tumors in rats during the estrous cycle","volume":"37","author":"Lee C","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.22.1.79"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1016\/S0021-9258(19)43410-8","article-title":"The specificity of cathepsin D","volume":"248","author":"Ferguson JB","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_1_17_2","first-page":"135","article-title":"Partial inhibition of castration\u2010induced involution in rat prostate by chloroquine. A preliminary observation","volume":"17","author":"Sharer WC","year":"1979","journal-title":"Invest Urol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-100-6-1550"},{"key":"e_1_2_1_19_2","volume-title":"Principles and Procedures of Statistics","author":"Steel RED","year":"1960"},{"key":"e_1_2_1_20_2","first-page":"145","volume-title":"The Prostatic Cell: Structure and Function, Part A","author":"Lee C","year":"1981"},{"key":"e_1_2_1_21_2","first-page":"19","article-title":"Partial inhibition of castration induced ventral prostate regression with actinomycin D and cycloheximide","volume":"16","author":"Stanisic T","year":"1978","journal-title":"Invest Urol"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990060107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990060107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:44:14Z","timestamp":1697892254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990060107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/pros.2990060107"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990060107","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}