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Amifloxacin concentrations in PS and PIF were lower than the corresponding P concentrations, as might be expected for an acid compound. There was no significant difference between the PS\/P and PIF\/P concentration ratios of the drug, and none exceeded 1.0. The concentrations of amifloxacin in PS, PIF, and prostatic tissue were above the minimal inhibitory concentration values of most gram\u2010positive bacteria causing chronic bacterial prostatitis. Clinical trials of amifloxacin seem justified.<\/jats:p>","DOI":"10.1002\/pros.2990060206","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:41:42Z","timestamp":1172018502000},"page":"163-168","source":"Crossref","is-referenced-by-count":4,"title":["Amifloxacin distribution in the dog prostate"],"prefix":"10.1002","volume":"6","author":[{"given":"P. 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Las Vegas NE: American Society for Microbiology 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy 24\u201326 October 1983 Abstract 376."},{"key":"e_1_2_1_7_2","unstructured":"IravantA WeltyG RicardGA: InVitro Activity of WIN 49375 a New Quinolone Against Urinary Pathogens of Acute Urinary Tract Infections. Las Vegas NE: American Society for Microbiology 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy 24\u201326 October1983 Abstract 377."},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"JacobusNV TallyFP BarsaM:Antimicrobial Spectrum of WIN 49375. Las Vegas NE: American Society for Microbiology 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy 24\u201326 October1983 Abstract 702.","DOI":"10.1128\/AAC.26.1.104"},{"key":"e_1_2_1_9_2","unstructured":"Sterling\u2010Winthrop Research Institute:Validation of an Analytical Method for the Quantitation of WIN 49375 in Plasma. 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