{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:38:48Z","timestamp":1789558728840,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":7140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010one patients have been treated for carcinoma of the prostate with <jats:sup>198<\/jats:sup> Au seeds placed transperineally using transrectal ultrasonic guidance. Twenty patients have been followed postoperatively for periods ranging from 3 to 31 months, with an average follow\u2010up time of 12 months. Cumulative dose of radiation to the prostate calculated by dosimetry was either 9,000 rads or 15,000 rads. Serial transrectal ultrasound examinations performed on these patients showed a decrease in prostate size in all patients within 6 months of treatment, with a statistically significant decrease observed between the third and sixth months. No significant difference in amount or rate of tumor regression was noted when tumor stage and grade were correlated to volume decrease after treatment. Patients who received the larger doses of radiation (15,000 rads) showed a significantly greater rate of decline in prostatic volume than those who received 9,000 rads. Seven patients underwent prostate biopsy between 12 and 18 months after treatment; six biopsies showed residual tumor. Complications after treatment included urinary retention because of prostatic edema (three), radiation urethritis (three), and rectal ulceration (one). Transperineal placement of <jats:sup>198<\/jats:sup>Au is well tolerated and offers an alternative to external beam radiation for treatment of carcinoma of the prostate.<\/jats:p>","DOI":"10.1002\/pros.2990110108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T01:12:29Z","timestamp":1172020349000},"page":"59-67","source":"Crossref","is-referenced-by-count":22,"title":["Percutaneous transperineal placement of gold 198 seeds for treatment of carcinoma of the prostate"],"prefix":"10.1002","volume":"11","author":[{"given":"Richard A.","family":"Crusinberry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene V.","family":"Kramolowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan A.","family":"Loening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0094-0143(21)01064-8","article-title":"Management of stage C prostatic carcinoma","volume":"2","author":"Flocks RH","year":"1975","journal-title":"Urol Clin North Am"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-5347(17)48892-6","article-title":"Radical prostatectomy with adjuvant radioactive gold for prostatic cancer: A preliminary report","volume":"133","author":"Rosenberg SJ","year":"1985","journal-title":"J Urol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)51108-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(87)90063-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860301)57:5<935::AID-CNCR2820570510>3.0.CO;2-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1425::AID-CNCR2820400411>3.0.CO;2-Q"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)55700-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)52763-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-5347(17)56765-8","article-title":"Carcinoma of the prostate: Local control with external beam radiation therapy","volume":"121","author":"Gibbons RP","year":"1979","journal-title":"J Urol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)57150-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990050103"},{"key":"e_1_2_1_13_2","first-page":"371","article-title":"Cancer of the prostate\u2010External radiotherapy","volume":"2","author":"Hafermann MD","year":"1983","journal-title":"Clin Oncol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)58349-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)60956-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)58448-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61201-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)47660-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45712-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56818-4"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990110108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990110108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:07:35Z","timestamp":1697846855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990110108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/pros.2990110108"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990110108","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}