{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:28:24Z","timestamp":1746505704418},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":7141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostate samples from 41 patients with acute on chronic prostatitis, benign hyperplasia, chronic prostatitis or adenocarcinoma were assayed for cytosolic retinoic acid binding protein (cRABP). Binding protein was detected in all samples. Scatchard analysis revealed dissociation constant values of 15.0\u201031.8 nM and maximum binding capacity of 5.2 \u00b1 2.0 (S.E.) pmo\/mg protein. Using sucrose density gradient centrifugation, cRABP was quantitated and values varied from 1.2 to 12.5 pmol\/mg protein. High levels (&gt; 3.5 pmol\/mg protein) were found in 28\/41 samples. There was no correlation between the cRABP binding\/mg protein and the volume (%) of glandular tissue (compared with stroma). While there was no significant difference in the quantities of cRABP in the different disease groups, there was a tendency for a progressive increase from acute on chronic prostatitis to chronic prostatitis, the highest levels being present in carcinoma.<\/jats:p>","DOI":"10.1002\/pros.2990110204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T01:11:46Z","timestamp":1172020306000},"page":"127-132","source":"Crossref","is-referenced-by-count":10,"title":["Cytosolic retinoic acid\u2010binding protein in human prostatic dysplasia and neoplasia"],"prefix":"10.1002","volume":"11","author":[{"given":"Jaswant K.","family":"Jutley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mikel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2528","article-title":"Chemoprevention of cancer with retinoids","volume":"38","author":"Spron MB","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_3_2","first-page":"381","article-title":"Growth pattern of mouse prostate gland in organ culture and its response to sex hormones, vitamin A and 3\u2010methylcholanthrene","volume":"12","author":"Lasnitski I","year":"1963","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.46.5.587"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1964.0017"},{"key":"e_1_2_1_6_2","first-page":"2510","article-title":"Cellular retinoid and retinoic acid\u2010binding proteins in vitamin A action","volume":"38","author":"Chytil F","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_7_2","first-page":"401","volume-title":"Recent Advances in Chemical Pathology, Series V","author":"Dunhill MS","year":"1968"},{"key":"e_1_2_1_8_2","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs","volume":"12","author":"Wiebel ER","year":"1963","journal-title":"Lab Invest"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1949.tb27297.x"},{"key":"e_1_2_1_11_2","first-page":"332","article-title":"Characterization of the retinol and retinoic acid binding proteins in the human prostate","volume":"44","author":"Boyd D","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","first-page":"207","volume-title":"Prostatic Cell: Structure and Function, Part B","author":"Brandes D","year":"1981"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1050157"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01947580"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91281-5"},{"key":"e_1_2_1_16_2","first-page":"2492","article-title":"Localization of retinoic acid: Binding protein in nuclei and the nuclear uptake of retinoic acid","volume":"39","author":"Sani B","year":"1979","journal-title":"Cancer Res"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990110204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990110204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:08:41Z","timestamp":1697994521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990110204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/pros.2990110204"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990110204","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}