{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:33:41Z","timestamp":1761762821968},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6044,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30\u2010month\u2010old animals demonstrated widespread epithelial atrophy, some foci of inflammation, in\u2010traglandular atypical hyperplasia and\/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low\u2010 and high\u2010molecular\u2010weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue\u2010type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe\u2010specific changes in activator activity appear related to dysplasia\/neoplasia and not aging.<\/jats:p>","DOI":"10.1002\/pros.2990160206","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T01:46:16Z","timestamp":1172022376000},"page":"147-161","source":"Crossref","is-referenced-by-count":20,"title":["Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging fischer 344 rats"],"prefix":"10.1002","volume":"16","author":[{"given":"Michael J.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet V.","family":"Ditmanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhouri A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Estensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"491","volume-title":"Biological Markers of Neoplasia: Basic and Applied Aspects","author":"Reich E","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-111-2-493"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.4.1029"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90301-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1016\/S0021-9258(18)89187-6","article-title":"Plasminogen activator in the rat ovary, production and gonadotropin regulation of the enzyme in granulosa and thecal cells","volume":"260","author":"Canipari R","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.1.86"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)90931-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.15.4939"},{"key":"e_1_2_1_10_2","first-page":"630","article-title":"Receptors for plasminogen activator, urokinase, in normal and rous Sarcoma virus\u2010transformed mouse fibroblasts","volume":"45","author":"Rosso MD","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(78)90216-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)91161-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1016\/S0021-9258(18)32636-X","article-title":"Regulation of extracellular plasminogen activator by human fibroblasts, the role of protease nexin","volume":"258","author":"Scott RW","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1016\/S0021-9258(17)35668-5","article-title":"Characterization of the dexamethasone\u2010induced inhibitor of plasminogen activator in HTC Hepatoma cells","volume":"261","author":"Coleman PL","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190504"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-7743(08)61367-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60361-9"},{"key":"e_1_2_1_18_2","first-page":"773","volume-title":"Tumor Cell Surfaces and Ma\u2010lignancy","author":"Quigley JP","year":"1980"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90093-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270211"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(84)90129-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(80)90239-1"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00288a015"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1016\/S0021-9258(17)33113-7","article-title":"Studies on the role of plasminogen activator in ovulation: in vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins","volume":"251","author":"Strickland S","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.875"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90338-3"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3962.1095"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/01485018208990252"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80039-X"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/51.4.1235"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/55.1.177"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990020304"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000225203"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990070310"},{"key":"e_1_2_1_37_2","first-page":"366","volume-title":"Sex and Internal Secretions","author":"Price D","year":"1961"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60951-6"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-67192-0_2","volume-title":"Prostate Gland and Seminal Vesicles","author":"Aumuller G","year":"1979"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1300-3"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990050510"},{"key":"e_1_2_1_42_2","first-page":"125","article-title":"A model for studies of the response of the ventral prostate to estrogens","volume":"97","author":"Corralea JJ","year":"1981","journal-title":"Acta Endocrinol"},{"key":"e_1_2_1_43_2","first-page":"145","volume-title":"The Prostatic Cell: Structure and Function","author":"Lee C","year":"1981"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990030505"},{"key":"e_1_2_1_45_2","first-page":"495","article-title":"The hypothalamic\u2010testicular function of the old rat","volume":"72","author":"Peng M\u2010T","year":"1973","journal-title":"J Formosan Med Assoc"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(79)90060-5"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(75)90039-2"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-1-128"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-102-2-540"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1040295"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90108-9"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2210171"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.3.723"},{"key":"e_1_2_1_54_2","first-page":"517","article-title":"Histogenesis and morphology on naturally occurring prostatic carcinoma in the ACI\/segHapBr rat","volume":"43","author":"Ward JM","year":"1980","journal-title":"Lab Invest"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/36.3.259"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/32.3.258"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.6.1693"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.6.1653"},{"key":"e_1_2_1_59_2","first-page":"311","article-title":"Plasminogen activator content and secretion in explants of neoplastic and benign human prostate tissues","volume":"44","author":"Camiolo SM","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60028-7"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38709-8"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990160206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990160206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T23:59:43Z","timestamp":1695772783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990160206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/pros.2990160206"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990160206","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}