{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:14:30Z","timestamp":1758816870810},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6044,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild\u2010type clinical isolate of <jats:italic>Escherichia coli.<\/jats:italic> Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.<\/jats:p>","DOI":"10.1002\/pros.2990170307","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T01:43:57Z","timestamp":1172022237000},"page":"233-239","source":"Crossref","is-referenced-by-count":11,"title":["Experimental prostatitis in nonhuman primates: II. Ascending acute prostatitis"],"prefix":"10.1002","volume":"17","author":[{"suffix":"Jr.","given":"Durwood E.","family":"Neal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Patrick","family":"Dilworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bernice","family":"Kaack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Didier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"161","volume-title":"Urinary Infection","author":"Stamey TA","year":"1972"},{"key":"e_1_2_1_3_2","first-page":"342","volume-title":"Pathogenesis and Treatment of Urinary Tract Infections","author":"Stamey TA","year":"1980"},{"key":"e_1_2_1_4_2","volume-title":"Advances in the Study of the Prostate","author":"Blacklock NJ","year":"1969"},{"key":"e_1_2_1_5_2","unstructured":"BlacklockNJ: The significance of the prostate in urinary tract infection in the male.Proc Soc Med505\u201358 1975."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198712000-00012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92797-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990170306"},{"key":"e_1_2_1_9_2","first-page":"205","article-title":"Trimethoprim diffusion into prostatic and salivary secretions of the dog","volume":"11","author":"Granato JJ","year":"1973","journal-title":"Invest Urol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/219139a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/4.2.475"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090660405"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/01485018308987471"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0022-5347(17)41346-2","article-title":"In vivo transfer of an R\u2010plasmid in a urinary tract infection model","volume":"141","author":"Neal DE","year":"1989","journal-title":"J Urol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0022-5347(17)51266-5","article-title":"Noninvasive localization of urinary tract infection: Clinical investigations and experience","volume":"130","author":"Janson KL","year":"1983","journal-title":"J Urol"},{"key":"e_1_2_1_16_2","first-page":"528","article-title":"Use of the rectal probe method for electroejaculation of apes, monkeys and a prosimian","volume":"17","author":"Fussell EN","year":"1967","journal-title":"Lab Anim Care"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.3.347"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990020106"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-5347(17)66949-0","article-title":"Semen cultures in the diagnosis of bacterial prostatitis","volume":"114","author":"Mobley DF","year":"1975","journal-title":"J Urol"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990170307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990170307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:22:49Z","timestamp":1697970169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990170307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/pros.2990170307"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990170307","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}