{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:33Z","timestamp":1762100613796},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal estrogenization of the mouse with diethylstilbestrol resulted in time\u2010of\u2010exposure and dose\u2010dependent inhibition of the growth of the prostatic lobes observed at the age of 2 mon. The critical time was the days 1\u20136 of postnatal life. In neonatally estrogenized (neoDES) mice, responses to 5\u03b1\u2010dihydrotestosterone in terms of nuclear <jats:sup>3<\/jats:sup>H\u2010thymidine labelling were altered concomitantly with the inhibition of growth and were in accordance with changes in the relative volumes of epithelium, glandular lumina, and interacinar stroma.<\/jats:p><jats:p>Secondary estrogen treatment of neoDES mice with 17\u03b2\u2010estradiol did not increase <jats:sup>3<\/jats:sup>H\u2010thymidine labelling in the prostate of control or neoDES mice. However, it induced squamous epithelial metaplasia in periurethral collecting ducts and proximal parts of coagulating glands of neoDES animals. In control mice only slight epithelial hyperplasia could be observed after similar treatment. Estrogen receptors, located immunocytochemically in nuclei of stromal cell, corresponded with the sites of increased estrogen sensitivity, observed as metaplastic transformation.<\/jats:p><jats:p>When the neoDES animals aged, epithelial hyperplasia and dysplasia could be observed at distinct prostatic sites, ie, the periurethral collecting ducts and the coagulating glands and periurethral glands, and stromal inflammation become more extensive. Almost identical location of the epithelial changes and the altered estrogen response is suggestive of causal relationship.<\/jats:p>","DOI":"10.1002\/pros.2990180204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T02:20:28Z","timestamp":1172024428000},"page":"117-129","source":"Crossref","is-referenced-by-count":67,"title":["Regional differences in the prostate of the neonatally estrogenized mouse"],"prefix":"10.1002","volume":"18","author":[{"given":"L.","family":"Pylkk\u00e4nen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Santti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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