{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:01Z","timestamp":1760188861151},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 15 patients with severe symptoms of prostadynia who were refractory to therapy were treated with transurethral microwave hyperthermia (TUHT) in a phase I trial. All patients had pain as the predominant symptom, 9 (60%) patients gave a history of psychological problems while frequency, urgency, dysuria, nocturia, and impotence were less common symptoms.<\/jats:p><jats:p>Treatment consisted of TUHT at 915 MHz given weekly for 5 weeks with a total of 68 treatment sessions and a mean of 4.5 treatments per patient. Each treatment lasted for 60 minutes. The aim was to increase the temperature measured on the urethral surface to \u226744\u00b0C. T mean for all sessions was 45.5\u00b0C. In 91% of treatments, the temperature was \u226744\u00b0C.<\/jats:p><jats:p>Treatment was well tolerated in 87% patients and acute toxicity was mild. Of the 15 patients treated, 2 (13%) did not complete the treatment course due to discomfort during TUHT.<\/jats:p><jats:p>Good treatment response, manifested by complete pain relief and a decrease in dysuria, was noted in 7 (47%) patients. A higher (\u2267 467\u00b0C) treatment temperature correlated well with good response, <jats:italic>P<\/jats:italic> &lt; .01. Similarly, relief of pain correlated well with the absence of a history of psychological problems, <jats:italic>P<\/jats:italic> &lt; .01. A decrease of obstructive micturition problems was noted in 5 of the 7 patients who had this upon presentation.<\/jats:p><jats:p>This study showed evidence of therapeutic activity with the use of TUHT in patients with prostadynia refractory to therapy. The response obtained was limited to less than one\u2010half of the patients. Complete pain relief was obtained in 4 (27%) patients. It is of interest to note that patients who had major benefit did not show evidence of psychological problems and were able to tolerate higher treatment temperatures. The latter could suggest a temperature\u2010related response.<\/jats:p>","DOI":"10.1002\/pros.2990190204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T02:08:46Z","timestamp":1172023726000},"page":"113-119","source":"Crossref","is-referenced-by-count":11,"title":["Transurethral microwave hyperthermia: An alternative treatment for prostadynia?"],"prefix":"10.1002","volume":"19","author":[{"given":"L.","family":"Baert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Willemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ameye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Astrahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Langholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"P\u00e9trovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0022-5347(17)56309-0","article-title":"Prostatosis, prostatitis or pelvic floor tension myalgia?","volume":"122","author":"Segura JW","year":"1979","journal-title":"J Urol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1975.tb04069.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(85)90450-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1981.tb03275.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)51281-1"},{"key":"e_1_2_1_7_2","first-page":"373","article-title":"Syndrome urethral de l'homme ou prostatodynie","volume":"22","author":"Bitker MO","year":"1988","journal-title":"Ann Urol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(87)90169-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0022-5347(17)40146-7","article-title":"Transurethral hyperthermia for benign prostatic hyperplasia: preliminary clinical results","volume":"143","author":"Sapozink MD","year":"1990","journal-title":"J Urol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39748-3"},{"key":"e_1_2_1_11_2","first-page":"373","article-title":"Bacteriologic localization patterns in bacterial prostatitis and urethritis","volume":"5","author":"Meares EM","year":"1988","journal-title":"Invest Urol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/02656739109004985"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/02656738909140455"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/02656739109004992"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38323-4"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990190204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990190204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:54:42Z","timestamp":1698029682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990190204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/pros.2990190204"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990190204","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}