{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:48:08Z","timestamp":1698144488644},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5314,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s.c. transplanted prostatic adenocarcinoma in relation to blood flow in normal tissues in rats. The blood flow was measured by using a radioactive microspheres technique. A bolus injection of 5 \u03bcg clonidine caused a decrease in the systemic blood pressure with 15\u201345 mm Hg, and blood flow to the central parts of the tumor, decreased with more than 50%. In the prostate, testes and ileo\u2010psoas muscle a similar reaction was seen. During an infusion of 95\u2013120 \u03bcg\/kg\/min dopamine, the blood pressure increased with 15\u201330 mm Hg, but the blood flow to the tumor was unchanged. However, in the testes and kidneys a decreased blood flow was observed. Moreover, mean blood flow to the central parts of the tumor decreased with increase in tumor size. The results further indicated that hyper\u2010 or hypotension or concomitantly given vasoactive drugs with the specific cancer treatment can have unwarranted effects on the distribution of cytotoxic drugs and oxygenation of the tumor.<\/jats:p>","DOI":"10.1002\/pros.2990200307","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T02:51:19Z","timestamp":1172026279000},"page":"225-232","source":"Crossref","is-referenced-by-count":7,"title":["Effects of clonidine\u2010induced hypotension and dopamine\u2010induced hypertension on blood flows in prostatic adenocarcinoma (dunning R3327) and normal tissues"],"prefix":"10.1002","volume":"20","author":[{"given":"\u00d6sten","family":"Jonsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Widmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Grankvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Erik","family":"Damber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Henriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"7680","article-title":"The control of tumour blood flow for therapeutic benefit","volume":"19","author":"Hirst DG","year":"1989","journal-title":"BIR Report"},{"key":"e_1_2_1_3_2","unstructured":"HirstDG:Tumour blood flow modification therapeutic benefit: Is this approach ready for clinical application? Gray Lab Annual Report1989."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90266-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/02656738809016490"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868909092250"},{"key":"e_1_2_1_7_2","first-page":"145","article-title":"Rationale for treatment of cancer with calcium antagonists","volume":"19","author":"Zacharski LR","year":"1988","journal-title":"J Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1988.tb00899.x"},{"key":"e_1_2_1_9_2","first-page":"351","article-title":"Prostatic cancer in the rat","volume":"12","author":"Dunning WF","year":"1963","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_1_10_2","first-page":"1447","article-title":"In vivo metabolism of testosterone 3H in R\u20103327, an androgen sensitive adenocarcinoma","volume":"34","author":"Voigt W","year":"1974","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_2","first-page":"784","volume-title":"Goodman & Gilman's, The Pharmacological Basis of Therapeutics","author":"Rudd P","year":"1985"},{"key":"e_1_2_1_12_2","first-page":"145","volume-title":"Goodman & Gilman's, The Pharmacological Basis of Therapeutics","author":"Weiner N","year":"1985"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1977.tb06009.x"},{"key":"e_1_2_1_14_2","first-page":"113","article-title":"Blood flow in the Dunning R3327H Rat prostatic adenocarcinoma; effects of oestradiol and testosterone","volume":"14","author":"Daelin L","year":"1986","journal-title":"Urol Res"},{"key":"e_1_2_1_15_2","unstructured":"JainRK: Delivery of novel therapeutic agents in tumors. Physiological barriers and strategies.JNCI570\u2013578 1981."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365518209168067"},{"key":"e_1_2_1_17_2","first-page":"2641","article-title":"Determinants of tumor blood flow: A review","volume":"48","author":"Jain RK","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_2","first-page":"4478","article-title":"Interstitial pressure gradients in tissue\u2010isolated and s. c. tumors: implications for therapy","volume":"50","author":"Boucher Y","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:1<60::AID-CNCR2820200109>3.0.CO;2-C"},{"key":"e_1_2_1_20_2","first-page":"143","volume-title":"Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors","author":"Vaupel P","year":"1979"},{"key":"e_1_2_1_21_2","first-page":"237","article-title":"Pattern of vasculature in two pairs of related fibrosarcomas in the rat and their relation to tumor responses to single large doses of radiation","volume":"14","author":"Falk P","year":"1978","journal-title":"Eur J Cancer Clin Oncol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(80)90152-8"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(82)90059-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.46"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90067-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940030507"},{"key":"e_1_2_1_27_2","first-page":"1","volume-title":"Tumour Circulation: Angiogenesis Vascular Morphology and Blood Flow Experimental and Human Tumours","author":"Warren BA","year":"1979"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01932474"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608052950606"},{"key":"e_1_2_1_30_2","first-page":"59","article-title":"Influence of vasoactive drugs on tumour blood flow","volume":"1","author":"Mattson J","year":"1981","journal-title":"Anticancer Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/ajplegacy.1972.223.1.241","article-title":"Dynamics of circulation in the testis of the conscious rat","volume":"223","author":"Free MJ","year":"1972","journal-title":"Am J Physiol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90249-7"},{"key":"e_1_2_1_33_2","first-page":"971","article-title":"Improvement of cancer therapy by angiotensin II\u2010induced hypertension chemotherapy","volume":"14","author":"Baba T","year":"1987","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90075-7"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715769009053372"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990200307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990200307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:15:04Z","timestamp":1698056104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990200307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/pros.2990200307"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990200307","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}