{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:07Z","timestamp":1761058627412},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":4947,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relation of prostatic intraepithelial neoplasia (PIN) or ductal dysplasia and the development of invasive prostate cancer is not clear. PIN, especially high grade, is usually associated with coexisting invasive cancer. Although some investigators have identified micro foci of invasive cancer evolving from PIN, the two are usually anatomically separated. Because of these distinct anatomic patterns, many investigators have concluded that PIN represents a \u201cfield effect\u201d or marker of potential cancer progression, and is not directly involved in or leads to the development of invasive prostate cancer.<\/jats:p><jats:p>We measured the DNA content in 49 foci of invasive cancer and 87 foci of PIN identified in 34 radical prostatectomies containing both PIN and invasive cancer. In addition, we examined 13 prostatectomies and 5 TUR specimens containing only PIN. We found that the majority of low grade PIN had normal or diploid range DNA and that approximately half of the high grade PIN were abnormal or aneuploid. Prostates with coexisting diploid range PIN and invasive cancer had an approximately equal number of diploid range and aneuploid invasive cancers. Conversely, almost all of the aneuploid PIN (usually high grade) had coexisting aneuploid invasive cancers. This would support the hypothesis that events in the progression of prostate cancer may be operative in both the development of PIN and invasive cancer. \u00a9 1993 Wiley\u2010Liss. Inc.<\/jats:p>","DOI":"10.1002\/pros.2990220208","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T02:38:24Z","timestamp":1172025504000},"page":"155-162","source":"Crossref","is-referenced-by-count":27,"title":["DNA quantitation of intraepithelial neoplasia and invasive carcinoma of the prostate"],"prefix":"10.1002","volume":"22","author":[{"given":"John D.","family":"Crissman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Edson","family":"Pontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90104-B"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870215)59:4<788::AID-CNCR2820590421>3.0.CO;2-I"},{"key":"e_1_2_1_4_2","first-page":"60A","article-title":"Significance of high grade prostatic intraepithelial neoplasia (PIN) or needle biopsy","volume":"66","author":"Weinstein MH","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_1_5_2","first-page":"354","article-title":"Prognostic significance of nuclear DNA content in localized prostate adenocarcinoma","volume":"12","author":"Peters JM","year":"1990","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_1_6_2","first-page":"161","article-title":"DNA content and survival in mammary carcinoma","volume":"3","author":"Auer G","year":"1980","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_1_7_2","first-page":"1249","article-title":"Image cytophotometric DNA analysis of atypical hyperplasias and intraductal carcinomas of the breast","volume":"114","author":"Crissman JD","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)59889-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90286-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.5.628"},{"key":"e_1_2_1_11_2","first-page":"119","article-title":"Phenotypic relationships of prostatic intraepithelial neoplasia to invasive prostatic cancer","volume":"138","author":"Nagle RB","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80156-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900515)65:10<2321::AID-CNCR2820651026>3.0.CO;2-B"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<555::AID-CNCR2820610322>3.0.CO;2-H"},{"key":"e_1_2_1_15_2","first-page":"366","article-title":"Quantitative analysis of prostatic intraepithelial neoplasia on tissue sections","volume":"12","author":"Montironi R","year":"1990","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_1_16_2","first-page":"52","article-title":"Prostatic intraepithelial neoplasia and invasive prostatic adenocarcinoma in cystoprostatectomy specimens","volume":"34","author":"Troncoso P","year":"1989","journal-title":"Urology"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0022-5347(17)60513-5","article-title":"Correlation between ploidy and prognosis in prostate carcinoma","volume":"109","author":"Tavarres AS","year":"1973","journal-title":"J Urol"},{"key":"e_1_2_1_18_2","first-page":"4084","article-title":"DNA ploidy by image analysis of individual foci of prostate cancer","volume":"51","author":"Greene DR","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_3","volume-title":"Nonparametric statistical methods","author":"Hollander Wolfe","year":"1973"},{"key":"e_1_2_1_19_2","volume-title":"Nonparametric statistical methods","author":"Hollander M","year":"1973"},{"key":"e_1_2_1_20_2","volume-title":"The analysis of case control studies","author":"Breslow NE","year":"1980"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990220208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990220208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T01:42:12Z","timestamp":1698198132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990220208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/pros.2990220208"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990220208","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}