{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:42:36Z","timestamp":1698309756871},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":4947,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Considering the advantages provided by the study of glandular secretions in proliferative diseases of the prostate, we carried out a study of 100 consecutive cases of benign hyperplasia (68), glandular dysplasia (12), and carcinoma (20). Samples were predominantly obtained by transurethral resection from patients whose mean ages were 64, 67, and 73.5 years, respectively. The paraffin embedded material was sectioned and stained with hematoxylin\u2010eosin, PAS\u2010diastase, PAS\u2010Alcian blue, methenamine silver, and Masson trichrome. Intraglandular secretion in normal, hyperplastic, and even neoplastic samples was predominantly neutral mucin, but in 2 cases of atypical adenomatous hyperplasia, and in all the carcinomas, we found acid mucin secretion. Holmes crystalloids were present in one case of nodular hyperplasia (1.4%), 2 cases of dysplasia (16.6%), and in 5 carcinomas (25%). As another manifestation of altered secretion, we also saw numerous needle\u2010shaped argyrophilic and isotropic crystalloids, not previously described, in 12 of the 20 carcinomas (60%). These crystalloids were exclusively found in the carcinomas, reached a size of 50 \u03bc, and were completely differentiated from the Holmes crystalloids by their odd needleshape and their staining characteristics. \u00a9 1993 Wiiey\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pros.2990220405","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T03:12:47Z","timestamp":1172027567000},"page":"309-315","source":"Crossref","is-referenced-by-count":5,"title":["Argyrophil crystalloids in adenocarcinoma of the prostate"],"prefix":"10.1002","volume":"22","author":[{"given":"Sebastian","family":"Luna\u2010Mor\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90250-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196408)17:8<983::AID-CNCR2820170804>3.0.CO;2-R"},{"key":"e_1_2_1_4_2","first-page":"395","article-title":"Histochemistry of mucus and other polysaccharides in tumors","volume":"16","author":"Hukill PB","year":"1967","journal-title":"Lab Invest"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.1.41"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90176-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90077-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700680233"},{"key":"e_1_2_1_9_2","first-page":"206","volume-title":"Tumors of the Male Genital System. Atlas of Tumor Pathology 2","author":"Mostofi FK","year":"1973"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(79)80095-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990130305"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197705)39:5<2073::AID-CNCR2820390525>3.0.CO;2-C"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990010105"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990010106"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860615)57:12<2397::AID-CNCR2820571226>3.0.CO;2-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990150306"},{"key":"e_1_2_1_17_2","unstructured":"Luna\u2010MoreS FlorezMP SantosA MartinA:Cristaloides en la prostata. Poster 22b Congreso Nacional SEAP Seville 23\u201325 May 1991."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198701000-00007"},{"key":"e_1_2_1_19_2","volume-title":"Theory and Practice of Histological Techniques","author":"Bancroft JD","year":"1982"},{"key":"e_1_2_1_20_2","first-page":"245","volume-title":"Electron Microscopy and Cytochemistry","author":"Rambourg A","year":"1973"},{"key":"e_1_2_1_21_2","first-page":"290","volume-title":"Handbook of Histopathological and Histochemical Techniques 3","author":"Culling CFA","year":"1974"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990220405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990220405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:06:54Z","timestamp":1698210414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990220405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/pros.2990220405"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990220405","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}