{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:34:04Z","timestamp":1793136844312,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4371,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between the serum values of prostate specific antigen (PSA) and the extent of histological prostatitis was investigated in 42 patients undergoing transurethral resection of the prostate for benign hyperplasia (BPH) without clinical evidence of prostatitis. Histological prostatitis was divided into three groups: acute, chronic\u2010active, and chronic\u2010inactive inflammation. The extent of histological prostatitis was expressed as the number of prostatic acinar and ductal glands with inflammatory infiltrate per total number of glands (%). The serum PSA values significantly correlated with the extent of acute and chronic\u2010active prostatitis (correlation coefficient r = 0.765 and 0.656, <jats:italic>P<\/jats:italic> &lt; 0.01). A relationship between PSA values and the extent of chronic\u2010inactive prostatitis was not found. In the immunohistochemical study, prostatic epithelial cells with acute and chronic\u2010active inflammation showed negative staining for PSA antigen. These results indicate that histological acute and chronic\u2010active prostatitis is considered an important factor for inducing the high increase in serum PSA values via the leak phenomenon. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pros.2990250206","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T03:38:48Z","timestamp":1172029128000},"page":"91-96","source":"Crossref","is-referenced-by-count":113,"title":["Relationship between serum prostate specific antigen and histological prostatitis in patients with benign prostatic hyperplasia"],"prefix":"10.1002","volume":"25","author":[{"given":"Yoshihiro","family":"Hasui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Marutsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamitsu","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"159","article-title":"Purification of a human prostate specific antigen","volume":"17","author":"Wang MC","year":"1979","journal-title":"Invest Urol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38491-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710083171501"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000472983","article-title":"Clinical behavior of prostatic specific antigen and prostatic acid phosphatase: A comparative study","volume":"14","author":"Morote\u2010Robles J","year":"1988","journal-title":"Eur Urol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(86)90146-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(89)90131-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990200205"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.6.760"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39757-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56980-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199210000-00008"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60101-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990200206"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40079-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37393-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35485-X"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpros.2990250206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.2990250206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:50:03Z","timestamp":1698144603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.2990250206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1002\/pros.2990250206"],"URL":"https:\/\/doi.org\/10.1002\/pros.2990250206","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}