{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:48:15Z","timestamp":1777877295739,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiotherapy is an essential treatment for various cancers, including prostate cancer (PCa), but it can lead to several adverse events, such as dysuria. While there is no gold standard treatment for this condition, some options, including herbal preparations, are suggested in traditional medicine. This study aimed to evaluate the efficacy of barley water compared to placebo in patients with PCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized placebo\u2010controlled study compared an oral barley water decoction to a placebo after adjuvant radiotherapy in patients with PCa at a clinic in Tehran, Iran. Patients received a daily decoction of barley water or placebo for 1 week and were followed for 8 weeks. Patients, physicians, outcome assessors, and statisticians were blinded to the assigned treatment. The primary outcome was radiotherapy\u2010induced dysuria, measured using the International Prostate Symptom Score (IPSS). Secondary outcomes included quality of life, analgesics use, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 90 PCa patients were randomized to barley water (<jats:italic>n<\/jats:italic>\u2009=\u200945) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200945). Analyses showed no significant differences in dysuria, quality of life, or analgesic use between the groups. Adverse events were similar for both groups; however, patient satisfaction was significantly higher in the barley water group (<jats:italic>p<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Barley water showed no clinical benefit over placebo in managing radiotherapy\u2010induced dysuria in PCa patients. This finding underscores the importance of rigorous clinical evaluation of herbal remedies and highlights the need for evidence\u2010based interventions to ensure patient safety and enhance quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.70008","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T09:37:10Z","timestamp":1753263430000},"page":"1272-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Efficacy of Barley Water in Alleviating Radiotherapy\u2010Induced Dysuria in Prostate Cancer Patients: A Randomized Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"85","author":[{"given":"Vida","family":"Nazari","sequence":"first","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center and Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Keshavarzian","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-2626","authenticated-orcid":false,"given":"Mehdi","family":"Pasalar","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Health Qom University of Medical Sciences Qom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-3510","authenticated-orcid":false,"given":"Bahram","family":"Mofid","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shohada\u2010e Tajrish Medical Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homa","family":"Hajimehdipoor","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Amin","family":"Annabi","sequence":"additional","affiliation":[{"name":"School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazaleh","family":"Heydarirad","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center and Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro6.1129"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2016.003954"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.11.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00151"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1446095"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16183130"},{"key":"e_1_2_11_8_1","volume-title":"Al\u2010Qanun fi al\u2010Tibb (The Canon of Medicine)","author":"Avicenna","year":"2005"},{"key":"e_1_2_11_9_1","volume-title":"Al\u2010Havi Fi Al\u2010Tibb (Arabic)","author":"Razi M. 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