{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:52:19Z","timestamp":1775832739889,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Forensic autopsies offer a unique opportunity to study the natural history of prostate cancer (PCa), especially in individuals who had no prior diagnosis or long\u2010term medical interventions. These examinations provide unbiased data on the true prevalence and progression of latent, asymptomatic prostate cancer. Unlike PSA screening\u2014which often leads to overdiagnosis and unnecessary treatment\u2014autopsy studies reveal clinically silent cases, particularly in older men. This prospective analysis was conducted to explore the prevalence and features of latent PCa in a South Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A study was conducted at a primary hospital in Vellore, Tamil Nadu, from August 2023 to April 2024. A total of 100 whole prostatectomy specimens were collected during forensic autopsies of male decedents aged 40\u201386 years, who had died under various medicolegal causes. Histopathological analysis was performed to identify the presence of latent prostate cancer. Data collected included basic history, cause of death, location of PCa, and Gleason scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological examination revealed that 9 out of 100 cases were diagnosed with invasive adenocarcinoma, with Gleason scores of 3\u2009+\u20093\u2009=\u20096 or 3\u2009+\u20094\u2009=\u20097, primarily in individuals aged over 60. The remaining 91 cases exhibited benign prostatic hyperplasia (BPH). These latent malignancies were more frequently found in individuals over the age of 60 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the role of forensic autopsies in detecting latent prostate cancer that may have gone undiagnosed during life. By providing insight into the frequency and characteristics of prostate cancer in a defined geographic and demographic context, the findings contribute to the understanding of its natural history. The results emphasize the need for age\u2010specific screening strategies and underscore the importance of comprehensive autopsy evaluations in uncovering hidden disease burdens in the population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.70010","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:57:31Z","timestamp":1751849851000},"page":"1227-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Latent Prostate Cancer: A Forensic Autopsy Study in South India"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2022-7410","authenticated-orcid":false,"given":"Ishvaria","family":"Sundaresan","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences School of Biosciences &amp; Technology, Vellore Institute of Technology Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-9772","authenticated-orcid":false,"given":"Nallasivam","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Department of Urology Henry Ford Health Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8502-6756","authenticated-orcid":false,"given":"Radha","family":"Saraswathy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Biosciences &amp; Technology, Vellore Institute of Technology Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.811044"},{"key":"e_1_2_10_3_1","unstructured":"International Agency for Research on Cancer and World Health Organization Global Cancer Observatory(World Health Organization 2022)."},{"issue":"8","key":"e_1_2_10_4_1","first-page":"1","article-title":"Prostate Cancer in India: Current Perspectives and the Way Forward","volume":"4","author":"Bhargavi R.","year":"2023","journal-title":"Journal of Reproductive Healthcare and Medicine"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-35118-1_14"},{"issue":"11","key":"e_1_2_10_6_1","article-title":"An in\u2010Depth Look Into the Epidemiological and Etiological Aspects of Prostate Cancer: A Literature Review","volume":"15","author":"Al\u2010Ghazawi M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153933"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000804"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119648628.ch10"},{"key":"e_1_2_10_10_1","first-page":"156","volume-title":"Forensic and Legal Medicine","author":"Burton J. 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