{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:57:22Z","timestamp":1777877842877,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aim to evaluate whether increased lymph node yield at prostatectomy (RP) is associated with improved outcomes in NRG\/RTOG 9601, a randomized clinical trial of men who underwent either radiation (RT) alone or RT\u2009+\u2009bicalutamide for PSA elevation following RP for pT2\/T3 prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed available pathology reports for patients in NRG\/RTOG 9601 to determine the nodal count at RP. Cox proportional hazards models were used to assess effect of lymph nodes yield, arm (RT alone or RT\u2009+\u2009bicalutamide), Gleason score, positive margins, and seminal vesicle invasion on the following endpoints: times to local and distant failure and overall and disease\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 760 patients, 552 (73%, 276 in each arm) had complete data available. Median node count in the entire cohort was 6 (range: 0\u201333, IQR: 3\u20139). There were no significant differences between arms in terms of patient demographic or clinical characteristics, including total lymph nodes removed in either arm. There was no significant association between total lymph nodes and overall or disease\u2010specific survival with both arms combined and when adjusting for arm. Notably, interaction analysis revealed that in seminal vesicle invasion, there was a significant association between lymph node yield and OS and DSS (HR\u2009=\u20090.91, 95% CI: 0.83\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.034; HR\u2009=\u20090.87, 95% CI: 0.77\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.029, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although lymph node yield in NRG\/RTOG 9601 did not show association with adverse outcomes in the entire cohort or either arm alone, there was significant association between lymph node yield and adverse outcomes when seminal vesicle invasion was present. The therapeutic benefit of extensive lymph node dissection remains uncertain but could be more relevant in higher risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.70018","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:59:25Z","timestamp":1753084765000},"page":"1315-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Impact of Lymph Node Yield in a Phase III Clinical Trial (NRG\/RTOG 9601) of Prostate Cancer Patients Treated With Salvage Radiation Following Prostatectomy"],"prefix":"10.1002","volume":"85","author":[{"given":"Emily","family":"Chan","sequence":"first","affiliation":[{"name":"University of San Francisco San Francisco California USA"},{"name":"Stanford University Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Pugh","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffry P.","family":"Simko","sequence":"additional","affiliation":[{"name":"University of San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Feng","sequence":"additional","affiliation":[{"name":"University of San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William U.","family":"Shipley","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu R.","family":"Lukka","sequence":"additional","affiliation":[{"name":"Juravinski Cancer Centre at Hamilton Health Sciences Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Bahary","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l'Universite de Montreal Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Pisansky","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth Lee","family":"Zeitzer","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-9060","authenticated-orcid":false,"given":"Elizabeth","family":"Gore","sequence":"additional","affiliation":[{"name":"The Medical College of Wisconsin and Milwaukee VAMC Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth A.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Sutter Cancer Centers Radiation Oncology Services Roseville California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G.","family":"Balogh","sequence":"additional","affiliation":[{"name":"Tom Baker Cancer Centre Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Lovett","sequence":"additional","affiliation":[{"name":"Rutland Regional Medical Center Rutland Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Wong","sequence":"additional","affiliation":[{"name":"University of San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-3758","authenticated-orcid":false,"given":"Robert T.","family":"Dess","sequence":"additional","affiliation":[{"name":"University of Michigan Comprehensive Cancer Center Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Scott","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Novant Health Presbyterian Medical Center Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kuettel","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luda","family":"DeMora","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard M.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.02.024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607529"},{"key":"e_1_2_10_5_1","unstructured":"https:\/\/www.nccn.org\/login?ReturnURL=https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/prostate.pdf(1\/26\/2024)."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2009.11.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.08.029"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.01.055"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.12.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.03.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64055-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000504"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23491"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.05.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000997"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:43:38Z","timestamp":1756215818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":16,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/pros.70018"],"URL":"https:\/\/doi.org\/10.1002\/pros.70018","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"2025-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}