{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:12:59Z","timestamp":1788358379395,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate surgical and cancer\u2010control outcome differences in robotic salvage radical prostatectomy (s\u2010RARP) patients after primary prostate cancer treatment with radiation (RT) versus focal therapy (FT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Junior ERUS\/Young Academic Urologist Working Group Robotics in Urology conducted a multicentric project to investigate biochemical recurrence\u2010free (BCR), metastases\u2010free (MFS) and overall survival outcomes in s\u2010RARP patients primarily treated with RT versus FT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 439 s\u2010RARP patients qualified for analyses, of which 54% initially received RT with a median time interval between primary cancer treatment and s\u2010RARP of 48 months. Patients with RT more frequently exhibited unfavorable oncological characteristics before s\u2010RARP (PSA, ISUP score), as well as pathological ISUP score (all \u2264\u20090.01), relative to FT patients. No differences in postoperative complications were observed (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.9). In BCR\u2010free analyses, no significant differences between RT and FT were observed (hazard ratio [HR]: 1.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.2). In MFS and OS analyses, patients with RT harbored a higher risk of metastases (HR: 10.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and death (HR: 5.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), relative to FT s\u2010RARP patients, but not after multivariable adjustment. In subgroup analyses of 201 FT patients, 80% received high\u2010intensified focused ultrasound (HIFU). No difference in BCR\u2010free survival was observed for HIFU\u2010 versus non\u2010HIFU s\u2010RARP patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Important differences in tumor characteristics between RT versus FT s\u2010RARP patients exist. These baseline differences translate into unfavorable short\u2010term MFS\u2010 and OS outcomes for RT s\u2010RARP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pros.70020","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:10:46Z","timestamp":1753333846000},"page":"1332-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oncological Outcomes After Robotic Salvage Radical Prostatectomy in Patients Primarily Treated With Focal Versus Radiation Therapy: A Junior ERUS\/YAU Collaborative Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Mike","family":"Wenzel","sequence":"first","affiliation":[{"name":"Department of Urology Goethe University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-2832","authenticated-orcid":false,"given":"Arjun","family":"Nathan","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Covas Moschovas","sequence":"additional","affiliation":[{"name":"AdventHealth Global Robotics Institute Celebration Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wagner","sequence":"additional","affiliation":[{"name":"Prostate Center Northwest, Department of Urology, Pediatric Urology and Uro Oncology St. Antonius\u2010Hospital Gronau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-1632","authenticated-orcid":false,"given":"Giorgio","family":"Calleris","sequence":"additional","affiliation":[{"name":"Urology Clinic, Department of Surgical Sciences University of Turin and Citt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-4808","authenticated-orcid":false,"given":"Fabrizio","family":"Di Maida","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence \u2010 Unit of Oncologic Minimally\u2010Invasive Urology and Andrology, Careggi Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gomez Rivas","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Andrea","family":"Bravi","sequence":"additional","affiliation":[{"name":"Department of Urology The Royal Marsden NHS Foundation Trust London UK"},{"name":"Department of Urology Onze\u2010Lieve\u2010Vrouwziekenhuis Hospital Aalst Belgium"},{"name":"ORSI Academy Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"De Groote","sequence":"additional","affiliation":[{"name":"Department of Urology Onze\u2010Lieve\u2010Vrouwziekenhuis Hospital Aalst Belgium"},{"name":"ORSI Academy Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Piramide","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Oncology, San Luigi Gonzaga Hospital University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Turri","sequence":"additional","affiliation":[{"name":"Department of Urology, ASST Santi Paolo e Carlo University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Urology MedStar Georgetown University Hospital Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"W\u00fcrnschimmel","sequence":"additional","affiliation":[{"name":"Department of Urology Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urologic Oncology Medanta The Medicity Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Andras","sequence":"additional","affiliation":[{"name":"Department of Urology Iuliu Hatieganu University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-4808","authenticated-orcid":false,"given":"Edward","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Urology Onze\u2010Lieve\u2010Vrouwziekenhuis Hospital Aalst Belgium"},{"name":"Department of Urology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Liakos","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Medical Centre of the University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Darlington","sequence":"additional","affiliation":[{"name":"Department of Urology, Stokes Centre for Urology Royal Surrey County Hospital Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paciotti","sequence":"additional","affiliation":[{"name":"Department of Urology Onze\u2010Lieve\u2010Vrouwziekenhuis Hospital Aalst Belgium"},{"name":"Department of Urology Humanitas Research Hospital\u2010 IRCCS Rozzano 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