{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:37:38Z","timestamp":1784425058298,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Men with a history of testicular cancer are known to have an increased risk of developing prostate cancer. The objective of this study is to determine if testicular cancer survivors are predisposed to a higher incidence of aggressive prostate cancer later in life and greater risks of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The Surveillance, Epidemiology, and End Results database was searched for patients diagnosed with prostate cancer and either no prior cancer diagnosis or a previous diagnosis (\u2265\u20095 years ago) of either testicular cancer or another cancer with a high survival rate (5\u2010year survival &gt;\u200970%). Cox regression models were used to determine the risk of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 392,238 prostate cancer patients, 423 had a history of testicular cancer, 31,428 had a history of another cancer, and 377,975 had no prior history of cancer. The mean ages of prostate cancer diagnosis were 62.53\u2009+\/\u2212\u20098.23 years, 67.95\u2009+\/\u2212\u20098.46 years, and 67.95\u2009+\/\u2212\u20099.47,\u00a0respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Testicular cancer was associated with earlier mortality on survival analysis in multivariable analysis controlling for age of prostate cancer diagnosis, race, clinical T stage, PSA level at diagnosis, and Gleason score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A history of testicular cancer may be associated with an increased risk of developing early prostate cancer and increased mortality. Confirmatory studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70035","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T17:59:28Z","timestamp":1755367168000},"page":"1481-1487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of the Increased Incidence of Aggressive Prostate Cancer After Prior Testicular Cancer"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-9352","authenticated-orcid":false,"given":"Kevin","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7502-8761","authenticated-orcid":false,"given":"Peter","family":"Evancho","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Riggin","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Shore Medical Center Easton Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Minhaj","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Maryland Medical Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"SEER Cancer Statistics Factsheets: Testis Cancer. National Cancer Institute. Bethesda MD http:\/\/seer.cancer.gov\/statfacts\/html\/testis.html."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0554-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji278"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.3409"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263573"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.034"},{"key":"e_1_2_8_8_1","unstructured":"A. M.Noone N.Howlader M.Krapcho et al.SEER Cancer Statistics Review 1975\u20102015 National Cancer Institute. Bethesda MD https:\/\/seer.cancer.gov\/csr\/1975_2015\/ Based on November 2017 SEER Data Submission Posted to the SEER web Site April 2018."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-472x(02)00802-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2014.07.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.05.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101169"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.564346"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:20:07Z","timestamp":1762852807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,16]]},"references-count":13,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pros.70035"],"URL":"https:\/\/doi.org\/10.1002\/pros.70035","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,16]]},"assertion":[{"value":"2025-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}