{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:26:35Z","timestamp":1780464395414,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>PSA response to apalutamide combined with androgen deprivation therapy (ADT) in metastatic hormone\u2010sensitive prostate cancer (mHSPC) has been linked to prognosis. Post hoc analyses from clinical trials suggest that PSA levels at 6 months are critical for predicting radiographic progression\u2010free survival (rPFS) and overall survival (OS). Real\u2010world evidence (RWE) is needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This multicentre, retrospective study included patients with mHSPC treated with apalutamide plus ADT from May 2018 to January 2025 across 18 Spanish centers. Patients were stratified according to PSA level at 6 months: Complete response (CR; \u2264\u20090.2\u2009ng\/mL) or incomplete response (IR; &gt;\u20090.2\u2009ng\/mL). The primary objective was to evaluate the association between PSA response and rPFS at 24 and 36 months. Univariate and multivariate Cox regression analyses were used to identify predictors of progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 812 patients, 65% achieved a CR at 6 months, associated with higher rPFS at 24 (94%) and 36 (81%) months compared to the IR group (73% and 60%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). CR (hazard ratio: 0.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and low\u2010volume disease (hazard ratio: 0.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independent predictors of rPFS. Baseline PSA, disease volume, and positron emission tomography imaging predicted achieving a CR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world cohort, PSA response at 6 months was a strong predictor of disease progression, supporting its use as a dynamic prognostic biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70040","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:35:43Z","timestamp":1756971343000},"page":"1507-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prostate\u2010Specific Antigen Response at Six Months Predicts Progression in Metastatic Hormone\u2010Sensitive Prostate Cancer Treated With Apalutamide"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-1596","authenticated-orcid":false,"given":"Christian Andr\u00e9s","family":"Mart\u00ednez Osorio","sequence":"first","affiliation":[{"name":"Instituto Valenciano de Oncolog\u00eda Valencia Spain"},{"name":"Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Sope\u00f1a Sutil","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Vilaseca Cabo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Linares Espin\u00f3s","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz Madrid 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dom\u00ednguez Estaban","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mu\u00f1oz Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Parc Taul\u00ed Sabadell Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Sanch\u00eds Bonet","sequence":"additional","affiliation":[{"name":"Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guijarro Cascales","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n de Alcorc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Beamud Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Servian Vives","sequence":"additional","affiliation":[{"name":"Hospital Universitari Germans Trias i Pujol Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"de la Morena Gallego","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Sof\u00eda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"P\u00e9rez M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Consorci Sanitari de Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Garc\u00eda Sanz","sequence":"additional","affiliation":[{"name":"Hospital Le\u00f3n Le\u00f3n 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Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:20:13Z","timestamp":1762852813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":15,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pros.70040"],"URL":"https:\/\/doi.org\/10.1002\/pros.70040","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"2025-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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