{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:49:52Z","timestamp":1764593392451,"version":"3.46.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salvage radiotherapy (RT) is a standard treatment for non\u2010metastatic prostate cancer recurrence after radical prostatectomy (RP), yet the efficacy of concurrent hormone therapy remains debated. This systematic review and meta\u2010analysis evaluates the impact of adding hormone therapy to adjuvant or salvage RT on key survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Scopus, Web of Science, and clinical trial registries for randomized phase 2 or 3 trials comparing RT alone versus RT with hormone therapy (anti\u2010androgens or androgen deprivation therapy) in patients undergoing RP. A random\u2010effects meta\u2010analysis with the inverse variance method was performed for overall survival (OS), metastasis\u2010free survival (MFS), and progression\u2010free survival (PFS) after extracting the corresponding hazard ratios (HR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four trials with generally low risk of bias were identified. Pooled HRs were 0.85 (95% CI: 0.72\u20130.99) for OS, 0.82 (95% CI: 0.70\u20130.96) for MFS, and 0.58 (95% CI: 0.51\u20130.66) for PFS, favoring hormone therapy. Following a sensitivity analysis that excluded the results of one of the four trials, the significance for OS was no longer observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hormone therapy with post\u2010RP RT significantly improves OS, MFS, and PFS in prostate cancer patients. Although the benefit in OS appears less robust, these findings support the significant role of hormone therapy in delaying disease progression.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>PROSPERO Registration Number:<\/jats:bold>\n                      CRD42024597336\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70056","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:39:32Z","timestamp":1758634772000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hormone Therapy With Salvage Radiotherapy After Radical Prostatectomy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"86","author":[{"given":"Reyhaneh","family":"Bayani","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Radiation Oncology, Hakim Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-5619","authenticated-orcid":false,"given":"Kasra","family":"Kolahdouzan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-9227","authenticated-orcid":false,"given":"Sepehr","family":"Nayebirad","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naeim","family":"Nabian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-2019","authenticated-orcid":false,"given":"Reza","family":"Ghalehtaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Alongi","sequence":"additional","affiliation":[{"name":"Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital Cancer Care Center Negrar Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3093-7924","authenticated-orcid":false,"given":"Nima Mousavi","family":"Darzikolaee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Radiation Oncology Research Center, Cancer Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.10.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.9607"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00705-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30486-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607529"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01790-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00548-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"M.Harrer P.Cuijpers T.Furukawa andD.Ebert Doing Meta\u2010Analysis With R: A Hands\u2010on Guide(Chapman and Hall\/CRC 2021).","DOI":"10.1201\/9781003107347"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.07.026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01662"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.9987"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.06.037"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.07.1416"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00549-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0390"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.401"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.5101"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2022.06.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31553-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109556"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.021"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:39:23Z","timestamp":1764592763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/pros.70056"],"URL":"https:\/\/doi.org\/10.1002\/pros.70056","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"type":"print","value":"0270-4137"},{"type":"electronic","value":"1097-0045"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"2025-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}