{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:06:40Z","timestamp":1770228400452,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of 5\u2010alpha reductase inhibitors (5\u2010ARIs) on Prostate Imaging Reporting and Data System (PI\u2010RADS) tumor classifications and prostate cancer (PCa) detection were reviewed and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A comprehensive systematic review and meta\u2010analysis were conducted by evaluating published studies examining the influence of 5\u2010ARIs on PI\u2010RADS lesions and PCa detection. The Web of Science, PubMed, and Embase databases were accessed for relevant study retrieval. Statistical analyses were performed through the use of STATA v.16.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies, comprising 12,132 participants, were included. Compared to men who had not received 5\u2010ARIs, those exposed to 5\u2010ARIs exhibited no significant differences in PCa diagnosis (OR 0.97, 95% CI 0.86\u20131.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55) or clinically significant PCa (csPCa) diagnosis (OR 1.01, 95% CI 0.89\u20131.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.85). Further subgroup analyses demonstrated that 5\u2010ARI\u2010exposed men had comparable PCa diagnosis in PI\u2010RADS 3 (OR 0.85, 95% CI 0.65\u20131.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25), PI\u2010RADS 4 (OR 1.01, 95% CI 0.85\u20131.21;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.84), and PI\u2010RADS 5 (OR 1.01, 95% CI 0.81\u20131.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.87) groups relative to 5\u2010ARI\u2010na\u00efve men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that 5\u2010ARIs do not significantly alter PI\u2010RADS lesion distribution or impact PCa and csPCa diagnosis. Consequently, exposure to 5\u2010ARIs should not influence MRI\u2010based diagnostic approaches in patients with suspected PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70066","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:35:12Z","timestamp":1759124112000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of 5\u2010Alpha Reductase Inhibitors on PI\u2010RADS Scores and Prostate Cancer Detection: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"86","author":[{"given":"Lian","family":"Qiong","sequence":"first","affiliation":[{"name":"Department of Radiology Lanzhou University Second Hospital Lanzhou Gansu P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qingyi","sequence":"additional","affiliation":[{"name":"Department of general surgical The People's Hospital of Guazhou County Jiuquan Gansu P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Bohong","sequence":"additional","affiliation":[{"name":"Department of Urology Gansu Provincial Hospital Lanzhou Gansu P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"YouCheng","sequence":"additional","affiliation":[{"name":"Department of Urology Gansu Provincial Hospital Lanzhou Gansu P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-0349","authenticated-orcid":false,"given":"Liu","family":"Qiangzhao","sequence":"additional","affiliation":[{"name":"Department of Urology Gansu Provincial Hospital Lanzhou Gansu P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.811044"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(14)70211-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(01)01298-5"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.06.006"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-2-14"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030660"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908127"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4858-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25891"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3696"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04634-2"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-023-01235-4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020193"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2024.65.417"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14222567"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24821"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54464-9"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0032"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.01.002"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.67"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2012.10.003"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.11.090"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25562"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00417-1"},{"issue":"10","key":"e_1_2_13_31_1","first-page":"761","article-title":"[The Influence of Benign Prostatic Hyperplasia Drugs on Incidence and Pathology Grading of Prostate Cancer]","volume":"48","author":"Zhu J.","year":"2010","journal-title":"Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1600"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.Epi-21-1234"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000001038"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.1501"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:32:41Z","timestamp":1765805561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/pros.70066"],"URL":"https:\/\/doi.org\/10.1002\/pros.70066","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,28]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}