{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:25:57Z","timestamp":1785266757458,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The limited resolution of standard transrectal ultrasound (TRUS) has made it difficult to perform biopsies of the prostate bed in cases of suspected local recurrence following radical prostatectomy. The aim of this study was to benchmark the performance of using high resolution micro\u2010ultrasound (microUS) in place of standard TRUS for performing post\u2010prostatectomy biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of pathology reports from January 2013 to October 2024, identifying patients who underwent biopsies of the prostate bed for suspected local recurrence after radical prostate. Sensitivity and specificity were compared for biopsies performed using standard TRUS. A biopsy was deemed diagnostic if it revealed prostate tissue (cancerous or benign) or non\u2010prostatic tissue when a previously suspicious lesion was no longer detectable on subsequent imaging. The ground truth for local recurrence was defined by biochemical recurrence (prostate\u2010specific antigen [PSA]\u2009\u2265\u20090.2\u2009ng\/mL in two consecutive measurements) accompanied by reproducible findings in the prostate bed on MRI and\/or PET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 24 patients included, 10 (42%) underwent microUS\u2010guided biopsy and 14 (58%) underwent TRUS\u2010guided biopsy. The median PSA levels at biopsy for the microUS and TRUS cohorts were 0.39\u2009ng\/mL (range 0.39\u20136.40) and 0.45\u2009ng\/mL (range 0.20\u201330.82), respectively. The median lesion sizes on MRI were 0.9\u2009cm (IQR 0.7\u20131.8) for microUS and 2.5\u2009cm (IQR 1.2\u20136) for TRUS. MicroUS demonstrated a sensitivity of 89% (95% CI: 52\u2013100), compared with 43% (95% CI: 18\u201371) for TRUS. Specificity could not be reliably assessed, as only one recurrence\u2010negative patient was available in the microUS group and none in the TRUS group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MicroUS\u2010guided transrectal biopsies appear to offer superior diagnostic performance in detecting local recurrences following radical prostatectomy compared to standard TRUS\u2010guided biopsy. Further study is needed to confirm our findings and to evaluate the performance of microUS\u2010guided biopsies independently of pre\u2010biopsy imaging results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70069","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T13:15:01Z","timestamp":1759670101000},"page":"189-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Value of Micro\u2010Ultrasound in Identifying Local Recurrence After Radical Prostatectomy"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-449X","authenticated-orcid":false,"given":"Basil","family":"Kaufmann","sequence":"first","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Urology University Hospital Zurich, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-1189","authenticated-orcid":false,"given":"Manish","family":"Choudhary","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-0933","authenticated-orcid":false,"given":"Ashutosh","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3294-0112","authenticated-orcid":false,"given":"Swati","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-7019","authenticated-orcid":false,"given":"Adriana","family":"Pedraza","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-7145","authenticated-orcid":false,"given":"Reuben","family":"Ben\u2010David","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-6792","authenticated-orcid":false,"given":"Asher","family":"Mandel","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-0486","authenticated-orcid":false,"given":"Neeraja","family":"Tillu","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-6661","authenticated-orcid":false,"given":"Vinayak G.","family":"Wagaskar","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Menon","sequence":"additional","affiliation":[{"name":"The Milton and Carroll Petrie Department of Urology Icahn School of Medicine at Mount Sinai New York New York 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