{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:36:32Z","timestamp":1785882992377,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To investigate the role of\n                      <jats:italic>HSD3B1<\/jats:italic>\n                      germline variant (1245C) in hormone therapy outcomes in Chinese prostate cancer (PCa) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multi\u2010center observational study was conducted enrolling 785 PCa patients who received primary androgen deprivation therapy (ADT) in China. Genotyping of germline variant and survival data were obtained, and clinical outcomes were analysed using Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up time was 31 months. In the entire study cohort, the\n                      <jats:italic>HSD3B1<\/jats:italic>\n                      variant (1245C) was significantly associated with a shorter time to castration resistance after adjusting for Gleason grade group (dominant model: hazard ratio, HR\u2009=\u20091.62, 95% confidence interval, 95% CI: 1.10\u20132.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015; additive model: HR\u2009=\u20091.55, 95% CI: 1.12\u20132.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Subgroup analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009438) with patients receiving only ADT for HSPC revealed a more significant association between the C allele and ADT failure (dominant model: HR\u2009=\u20092.37, 95% CI: 1.49\u20133.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; additive model: HR\u2009=\u20091.93, 95% CI: 1.34\u20132.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among patients who received next\u2010generation hormone therapy after ADT failure, the C allele was associated with poorer abiraterone response (HR\u2009=\u20093.02, 95% CI: 1.07\u20138.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037); however, no significant change of response from enzalutamide was observed (HR\u2009=\u20090.98, 95% CI: 0.27\u20133.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.972).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>HSD3B1<\/jats:italic>\n                      germline variant (1245C) is linked to earlier ADT failure and diminished efficacy of abiraterone but does not affect enzalutamide in the treatment of PCa patients. These findings underscore its potential as a biomarker to guide personalized treatment in PCa.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70089","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:52:06Z","timestamp":1762282326000},"page":"329-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Germline\n                    <i>HSD3B1<\/i>\n                    Variant Is Associated With Response to Androgen Deprivation Therapy and Abiraterone but not With Response to Enzalutamide in Chinese Prostate Cancer Patients"],"prefix":"10.1002","volume":"86","author":[{"given":"Ruofan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Urology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Urology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Chun Yin","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsun Tsun Stacia","family":"Chun","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang Philip","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-7072","authenticated-orcid":false,"given":"Tsz Yeung","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salida","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-5108","authenticated-orcid":false,"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100962"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"365","article-title":"Mechanisms of Resistance in Castration\u2010Resistant Prostate Cancer (CRPC)","volume":"4","author":"Chandrasekar T.","year":"2015","journal-title":"Translational Andrology and 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