{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T12:27:22Z","timestamp":1768048042623,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to determine whether TL\u2010PSMA, PSMA\u2010TV, and SUVpeak values measured in prostate adenocarcinoma patients who underwent imaging with Ga\u201068 PSMA PET\/CT for primary staging have a role in predicting treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Images of 68 patients who underwent Ga\u201068 PSMA PET\/CT for primary staging between March 25, 2019, and December 3, 2021, were analyzed retrospectively. Volumetric parameter data were obtained through manual delineation using a 40% threshold for the prostate gland, lymph nodes, bone, and visceral organ metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TL\u2010PSMA(Bone) measurement differed statistically significantly between the treatment\u2010responsive and unresponsive groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). In addition, TL\u2010PSMA and PSMA\u2010TV parameters showed statistically significant differences between the treatment\u2010responsive and unresponsive groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). We could not find a significant relationship between other volumetric parameters and treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It has been established that the volumetric parameters derived from Ga\u201068 PSMA PET\/CT imaging conducted for primary staging may play a role in predicting treatment response in patients with prostate adenocarcinoma. However, further studies involving larger patient populations are necessary to clarify this issue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70094","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:32:28Z","timestamp":1762342348000},"page":"372-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Volumetric Parameters Derived From Ga\u201068 PSMA PET\u2010CT in Predicting Treatment Response"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-9018","authenticated-orcid":false,"given":"Ali","family":"Uyar","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine \u2013 Bilecik Bilecik Training and Research Hospital  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-0341","authenticated-orcid":false,"given":"Bekir","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine \u2013 Diyarbak\u0131r Dicle University Medical Faculty  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-5358","authenticated-orcid":false,"given":"\u015eadiye Altun","family":"Tuzcu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine \u2013 Diyarbak\u0131r Dicle University Medical Faculty  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-2941","authenticated-orcid":false,"given":"Zeynep","family":"Oru\u00e7","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\u2013 Diyarbak\u0131r Dicle University Medical Faculty  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-136X","authenticated-orcid":false,"given":"Halil","family":"K\u00f6mek","sequence":"additional","affiliation":[{"name":"Diyarbak\u0131r Gazi Ya\u015fargil Health Research Center, Department of Nuclear Medicine Un\u0131versity of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2016.08.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051517-011947"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.223099"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.193581"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"25","article-title":"Role of 68Ga\u2010PSMA PET\/CT Parameters in Treatment Evaluation and Survival Prediction in Prostate Cancer Patients Compared With Biochemical Response Assessment","volume":"24","author":"Can C.","year":"2021","journal-title":"Hellenic Journal of Nuclear Medicine"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122938"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-025-07519-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4236-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2014.06.010"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4042-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001431"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-019-01387-0"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071575"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-4258-6"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:51:57Z","timestamp":1768035117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/pros.70094"],"URL":"https:\/\/doi.org\/10.1002\/pros.70094","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}