{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:41:39Z","timestamp":1789962099455,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To evaluate the diagnostic accuracy, procedural feasibility, and clinical outcomes of a novel cystoscopic\u2010guided indocyanine green (ICG) injection technique followed by fluorescence\u2010guided sentinel lymph node dissection (SLND) during robotic\u2010assisted radical prostatectomy (RaRP), hereafter referred to as\n                      <jats:bold>CysICG\u2010SLND<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled patients with clinically localized prostate cancer (cT1\u2013cT3, cN0) scheduled for RaRP between November 2019 and May 2020. Each patient received cystoscopic\u2010guided intraprostatic injections of ICG, with injection volumes tailored according to prostate size. SLND was performed using the da Vinci Xi Surgical System equipped with near\u2010infrared imaging and followed by a routine extended pelvic lymph node dissection (ePLND). Diagnostic accuracy, procedural complications, and medium\u2010term oncological outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 patients were included (risk category: low\u2009=\u20092, intermediate\u2009=\u200911, high\u2009=\u200921). Cystoscopic ICG injection was technically successful in all cases. The overall fluorescence detection rate was 97.1%, with excellent per\u2010patient sensitivity (100%) and negative predictive value (NPV) (100%) across all patients. However, per\u2010node diagnostic performance was moderate (sensitivity 66.7%, specificity 47.8%). Notably, in the high\u2010risk group, per\u2010node performance was modest, with sensitivity, specificity, positive predictive value (PPV), and NPV of 66.7%, 55.2%, 20.5%, and 90.7%, respectively. No metastatic nodes were identified in low\u2010risk and intermediate\u2010risk groups, demonstrating a reliable 100% NPV in these subpopulations. High\u2010risk patients had significantly higher biochemical recurrence (BCR) rates compared to lower\u2010risk groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). There were no allergic reactions or postoperative complications attributable to ICG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CysICG\u2010SLND is a feasible, accurate approach for nodal staging in prostate cancer, particularly beneficial in low\u2010 to intermediate\u2010risk groups, achieving excellent sensitivity and NPV. Although diagnostic performance is limited in high\u2010risk patients, high per\u2010patient accuracy still supports clinical utility. Larger prospective studies are warranted to validate these results and further elucidate the technique's clinical role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70107","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T07:41:50Z","timestamp":1766562110000},"page":"481-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cystoscopic ICG\u2010Guided Sentinel Lymph Node Dissection in Robotic Radical Prostatectomy: A Prospective Study"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-6467","authenticated-orcid":false,"given":"Yi Hong","family":"Li","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Feng","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Chuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Chun","family":"Weng","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao Yu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Che","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.02.001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.12.003"},{"key":"e_1_2_13_4_1","unstructured":"Guidelines E. 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