{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:11:48Z","timestamp":1788909108971,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the relationship between the gut microbial profiles, occurrence of side effects, total testosterone (TS) levels, and pretreatment dietary habits among patients with high\u2010risk localized prostate cancer who were subjected to androgen\u2010deprivation therapy (ADT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included patients diagnosed with high\u2010risk localized prostate cancer who underwent ADT between March 2021 and August 2022. The correlation between the pre\u2010 and post (after 3 months)\u2010ADT gut microbial profiles, laboratory tests, body consumption data, and pretreatment dietary habits was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were observed in the alpha\u2010 and beta\u2010diversities of the gut microbiota during pre\u2010 and post\u2010ADT. The relative abundance of genus\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and genus [\n                      <jats:italic>Eubacterium<\/jats:italic>\n                      ]\n                      <jats:italic>ruminantium<\/jats:italic>\n                      group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) were significantly higher during post\u2010ADT compared with those during pre\u2010ADT. Twenty percent of the patients with a post\u2010ADT TS level of &lt;\u200920\u2009ng\/dL had a significantly high proportion of genus\n                      <jats:italic>Ruminococccus<\/jats:italic>\n                      2, whereas no significant proportion was observed in patients with a TS level of \u2265\u200920\u2009ng\/dL. In terms of the impact of the pretreatment dietary habits on the changes of the gut microbiota, genus\n                      <jats:italic>Romboutsia<\/jats:italic>\n                      and genus\n                      <jats:italic>Fusicatenibacter<\/jats:italic>\n                      showed a positive correlation with n\u20106 polyunsaturated fatty acid intake, whereas the amounts of genus\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      2 and genus\n                      <jats:italic>Veillonella<\/jats:italic>\n                      showed a negative correlation with n\u20103 polyunsaturated fatty acids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Short\u2010term ADT was found to increase the proportion of gut genus\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      2 in patients with advanced prostate cancer, which was associated with low TS levels and showed a negative correlation with n\u20103 polyunsaturated fatty acid intake. Further validation is important to identify specific changes in the gut microbiota during ADT in patients with prostate cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70109","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:56:07Z","timestamp":1765637767000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Androgen\u2010Deprivation Therapy and Dietary Habits Influence the Gut Microbial Environment in Patients With High\u2010Risk Localized Prostate Cancer"],"prefix":"10.1002","volume":"86","author":[{"given":"Masanori","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Urology Akita University Graduate School of Medicine Akita Japan"},{"name":"Oshu City National Health Insurance Magokoro Hospital Oshu 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