{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:58:08Z","timestamp":1774997888712,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In real\u2010world practice in Japan, standard treatment for metastatic hormone\u2010na\u00efve prostate cancer (mHNPC) is androgen deprivation therapy (ADT), administered as monotherapy, combined androgen blockade (CAB), ADT plus androgen receptor pathway inhibitors (ARPIs), or ADT plus docetaxel. In a previous interim analysis of the large\u2010scale, longitudinal, multicentre, J\u2010ROCK registry study of real\u2010world clinical and patient\u2010reported outcomes, ADT plus ARPI or ADT plus docetaxel was used more frequently than ADT\/CAB in patients (aged\u2009\u2265\u200920 years) with newly diagnosed LATITUDE\u2010criteria high\u2010risk mHNPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc analysis of the J\u2010ROCK study evaluated prostate\u2010specific antigen (PSA) response, progression\u2010free survival (PFS), time to castration\u2010resistant prostate cancer (CRPC), overall survival (OS) and safety in patients with high\u2010risk mHNPC who received ADT\/CAB (cohort 1) or ADT plus ARPI (cohort 2B) in subgroups were defined according to the following known prognostic factors at baseline: age, Gleason Grade Group (GGG), alkaline phosphatase (ALP), hemoglobin (Hb) and lactate dehydrogenase (LDH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This analysis included 947 evaluable patients (371 in cohort 1 and 576 in cohort 2B). PSA response rates remained similar among age and GGG subgroups in both cohorts, but were reduced in cohort 2B patients with elevated ALP, low Hb, and elevated LDH. Time to CRPC and OS were longer in cohort 2B than in cohort 1, regardless of prognostic factors. Among patients with poor prognosis (older, high GGG, low Hb, elevated LDH), OS decline occurred earlier in cohort 1 versus cohort 2B. A trend towards a plateau in the time to CRPC curve was observed in both cohorts, even in patients with poor prognosis. Safety data were not affected by prognostic factors or treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that novel ADT plus ARPI regimens for LATITUDE\u2010criteria high\u2010risk mHNPC may improve real\u2010world outcomes compared with ADT monotherapy or CAB, particularly among patients with poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70118","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T18:21:56Z","timestamp":1768242116000},"page":"599-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post Hoc Subgroup Analysis of Clinical Outcomes in Patients With High\u2010Risk Metastatic Hormone\u2010Na\u00efve Prostate Cancer: Results From a 3\u2010Year Interim Analysis of the J\u2010ROCK Study"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-2182","authenticated-orcid":false,"given":"Atsushi","family":"Mizokami","sequence":"first","affiliation":[{"name":"Department of Urology Kanazawa University Hospital Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikiya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Chutoen General Medical Center Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-4160","authenticated-orcid":false,"given":"Hideaki","family":"Miyake","sequence":"additional","affiliation":[{"name":"Division of Urology Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-1564","authenticated-orcid":false,"given":"Hiroji","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Yokohama City University Graduate School of Medical Science  Kanagawa Japan"},{"name":"Prostatic Disease Center Shonan Kamakura General Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-9523","authenticated-orcid":false,"given":"Hirotsugu","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-3821","authenticated-orcid":false,"given":"Satoru","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Urology, Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8308-921X","authenticated-orcid":false,"given":"Kazuyoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology Kimitsu Chuo Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-2831","authenticated-orcid":false,"family":"Shigekatsu Maekawa","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University Hospital Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-7298","authenticated-orcid":false,"given":"Hiroaki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Johnson &amp; Johnson Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachie","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Medical Affairs Delivery Unit, Global Development Johnson &amp; Johnson R&amp;D Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2684-3873","authenticated-orcid":false,"given":"Eri","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Johnson &amp; Johnson Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9800-2105","authenticated-orcid":false,"given":"Ryo","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Johnson &amp; Johnson Tokyo Japan"},{"name":"Medical Affairs Company, CMIC Inizio Co. 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