{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:37:57Z","timestamp":1772998677874,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To question the necessity of simultaneous benign prostatic obstruction (BPO) intervention with cystolitholapaxy in patients with bladder stone (BS) due to BPO and to investigate the factors predicting secondary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 235 male patients over 40 years of age who underwent cystolitholapaxy, had a follow\u2010up period longer than 12 months, and were thought to have BS secondary to BPO were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 190 patients who did not require additional intervention were defined as Group 1, and 45 patients who required secondary intervention were defined as Group 2. Secondary surgical intervention was required at a rate of 19.5% with an average follow\u2010up of 49 months. Mean peak urine flow rate (\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) was 11\u2009m\/s in Group 1 and 8.6\u2009m\/s in Group 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), postvoid residual urine volume (PVR) was 85.5\u2009mL in Group 1 and 115.3\u2009mL in Group 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), International Prostate Symptoms Score (IPSS) was 16.7 in Group 1 and 21.7 in Group 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Total prostate volume (TPV) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and serum prostate\u2010specific antigen (PSA) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) were also significantly higher in Group 2. In the multivariable Cox proportional hazards regression analysis of factors predicting secondary intervention in patients undergoing cystolitholapaxy, low\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      (hazard ratio (HR)\u2009=\u20090.905, 95% confidence interval (CI): 0.821\u20130.997,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), high PVR (HR\u2009=\u20091.014, 95% CI: 1.007\u20131.022,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), high IPSS (HR\u2009=\u20091.178, 95% CI: 1.106\u20131.255,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and high PSA (HR\u2009=\u20091.086, 95% CI: 1.000\u20131.178,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) were found to be predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In patients with BS secondary to BPO, performing cystolitholapaxy offers a high likelihood of avoiding secondary intervention. Low\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      , high PVR, high IPSS, and high PSA are indicators of a higher risk of secondary intervention in the preoperative period. Therefore, in a patient\u2010centered approach, these predictors should be taken into account when deciding whether BPO surgery is necessary in addition to cystolitholapaxy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70123","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:43:28Z","timestamp":1767692608000},"page":"592-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Cystolitholapaxy Sufficient in Patients With Bladder Stones Secondary to Benign Prostatic Obstruction?"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-6790","authenticated-orcid":false,"given":"Mert Hamza","family":"\u00d6zbilen","sequence":"first","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital Health Sciences University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-0302","authenticated-orcid":false,"given":"Mahmut Can","family":"Karabacak","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Tepecik Health Practice and Research Hospital Health Sciences University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-5577","authenticated-orcid":false,"given":"Taylan","family":"T\u0131\u011fl\u0131","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Tepecik Health Practice and Research Hospital Health Sciences University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-0435","authenticated-orcid":false,"given":"Mehmet","family":"Yolda\u015f","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Tepecik Health Practice and Research Hospital Health Sciences University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-4260","authenticated-orcid":false,"given":"\u00dcmit","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital Health Sciences University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-5586","authenticated-orcid":false,"given":"Mehmet Zeynel","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Tepecik Health Practice and Research Hospital Health Sciences University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-9378","authenticated-orcid":false,"given":"G\u00f6khan","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Urology, Medicalpoint International Hospital Izmir University of Economics Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-1965","authenticated-orcid":false,"given":"Zafer G\u00f6khan","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital Health Sciences University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70262-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/03915603211020469"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.09.014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00383-016-3876-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0393-2249.17.02972-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2012.11.027"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282696"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.842008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00345-023-04699-Z\/METRICS"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.UROLOGY.2010.10.035"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JURO.2012.11.079"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURURO.2004.05.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11255-005-0247-8"},{"key":"e_1_2_11_15_1","unstructured":"H.Grosse \u201cFrequency Localization and Associated Disorders in Urinary Calculi. 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