{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:28:44Z","timestamp":1791340124553,"version":"4.3.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>It is unknown whether marital status affects years of life lost (YLL) in metastatic prostate cancer (mPCa) according to race\/ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within the SEER database (2004\u20132021), unmarried and married mPCa patients aged 40\u201380 years were identified. Age\u2010 and sex\u2010matched controls were generated (Social Security Administration life tables and Monte Carlo simulation). YLL were quantified for unmarried and married mPCa patients\u00a0and controls according to race\/ethnicity. Subsequently, multivariable competing risks regression (CRR) models were fitted to assess cancer\u2010specific mortality (CSM) and other\u2010cause mortality (OCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 34,202 mPCa patients, the distribution of unmarried patients according to race\/ethnicity was as follows: 7267 (34.0%) in Caucasians; 3680 (57.0%) in African Americans; 1659 (37.0%) in Hispanics; and 478 (24.0%) in Asians\/Pacific Islanders. YLL values in unmarried vs. married patients relative to age\u2010 and sex\u2010matched population simulated controls, were as follows: 7.7 vs. 5.8 in Caucasians (\u0394: 1.9), 9.6 vs. 7.9 in African Americans (\u0394: 1.7), 7.9 vs. 6.7 in Hispanics (\u0394: 1.2), and 6.3 vs. 4.7 in Asians\/Pacific Islanders (\u0394: 1.6). In multivariable CRR models, unmarried status independently predicted higher CSM (1.2\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and OCM (1.2\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in Caucasians, only higher CSM in African Americans (1.1\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and in Asians\/Pacific Islanders (1.2\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), but only higher OCM in Hispanics (1.5\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unmarried mPCa patients exhibited higher YLL values than their married counterparts, relative to age\u2010 and sex\u2010matched population simulated controls, across all races\/ethnicities. Interestingly, the YLL detriments originated from both CSM and OCM in Caucasians, only CSM in African Americans and Asians\/Pacific Islanders, and only OCM in Hispanics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70130","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:07:56Z","timestamp":1769108876000},"page":"676-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Marital Status on Years of Life Lost From Metastatic Prostate Cancer According to Race\/Ethnicity"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9523-3400","authenticated-orcid":false,"given":"Leonardo","family":"Quarta","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Polverino","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Petix","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology ASST Santi Paolo e Carlo Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5715-9965","authenticated-orcid":false,"given":"Maximilian","family":"Filzmayer","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology, University Hospital Goethe University Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-0503","authenticated-orcid":false,"given":"Nick J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology, AOU di Modena University of Modena and Reggio Emilia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4609-8981","authenticated-orcid":false,"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Urology ASST Santi Paolo e Carlo Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K. H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Goethe University Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Micali","sequence":"additional","affiliation":[{"name":"Department of Urology, AOU di Modena University of Modena and Reggio Emilia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Weill Cornell Medical College New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas Texas USA"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-3217","authenticated-orcid":false,"given":"Francesco","family":"Barletta","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Stabile","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.6489"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.10993.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.3204"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"6702","article-title":"Marital Status and Prostate Cancer Outcomes","volume":"20","author":"Tyson M. 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