{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:17:17Z","timestamp":1780399037024,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction and Objectives<\/jats:title>\n Post\u2010surgical urinary incontinence (PSI) can occur after benign prostatic hyperplasia (BPH) surgery. Estimating incontinence risks across modalities largely relies upon reports from single surgeons or expert groups. Real\u2010world data (RWD) provides a broader view of practice settings and surgeon experience. We used RWD to assess the incidence, duration, and risk factors of PSI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective cohort study using U.S. healthcare system electronic health records data compiled by Truveta of 97,970 men who underwent transurethral resection of the prostate, endoscopic enucleation, photoselective vaporization, prostatic urethral lift, water vapor thermal therapy, or robotic waterjet therapy from 2017 to 2024. Continence was defined by absence of incontinence codes or supplies for \u2265\u20092 consecutive encounters, or a continence restoring procedure. Incontinence rates were estimated using Kaplan\u2010Meier methods.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PSI occurred in 6.9% of patients across all procedures within 1 month of surgery, decreasing to 3.8% at 18 months and 2.3% at 3 years. Adjusted for age and BPH procedure, rates of persistent PSI (18 months to 3 years) were independently highest with polyuria (\n p<\/jats:italic>\n \u2009<\u20090.0001), neurological disorders (\n p<\/jats:italic>\n \u2009<\u20090.0001), and sleep apnea (\n p<\/jats:italic>\n \u2009<\u20090.0001). Those with baseline pre\u2010surgical urinary retention (\n p<\/jats:italic>\n \u2009<\u20090.0001), essential hypertension (\n p<\/jats:italic>\n \u2009=\u20090.003), chronic kidney disease (\n p<\/jats:italic>\n \u2009<\u20090.0001), and anticholinergic medications (\n p<\/jats:italic>\n \u2009=\u20090.00016) were less likely to experience persistent incontinence.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n While PSI decreased over time, 3.8% had persistent incontinence at 18 months. Certain co\u2010morbidities were associated with higher PSI rates. RWD can provide a comprehensive view of incontinence risk in real\u2010world practice, however, utilizing RWD to determine resolution of incontinence is challenging.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pros.70146","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:59:27Z","timestamp":1772989167000},"page":"792-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of Real\u2010World Evidence in the Evaluation of Post\u2010Surgical Incontinence in Men Undergoing Surgical Treatment for Benign Prostatic Hyperplasia"],"prefix":"10.1002","volume":"86","author":[{"given":"Zizwa","family":"Mwafulirwa","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roane","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline","family":"Andrew","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-4575","authenticated-orcid":false,"given":"Lori B.","family":"Lerner","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000003698"},{"key":"e_1_2_11_3_1","unstructured":"U.S. Food and Drug Administration Real\u2010World Evidence https:\/\/www.fda.gov\/science-research\/science-and-research-special-topics\/real-world-evidence."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/s2724-6051.24.05802-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000004285"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312869"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0319434"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.06.063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2010.0021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.03.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaf119"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9569"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.04.358"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2022.09.2270"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:43:36Z","timestamp":1780397016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/pros.70146"],"URL":"https:\/\/doi.org\/10.1002\/pros.70146","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}