{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:52:13Z","timestamp":1777945933051,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calcitonin (CT) and its receptor promote prostate cancer (PC) progression and metastasis. Identifying downstream CT\u2010regulated genes may provide clinically useful biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subtraction hybridization was used to identify CT\u2010inducible genes. Expression of zinc finger protein\u2010like 1 (ZFPL1) was examined in malignant versus benign prostate tissues and evaluated for regulation by CT and androgens. Exosomal secretion of ZFPL1 protein was assessed, and plasma levels were measured in PC patients compared with cancer\u2010free individuals. Immunohistochemistry was performed to assess ZFPL1 localization with neuroendocrine (NE) and stem cell markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ZFPL1 was strongly expressed in malignant prostates but nearly absent in benign tissues. Its expression was upregulated by both CT and androgens. ZFPL1 protein was secreted through exosomes, and plasma concentrations in PC patients were at least fourfold higher than in cancer\u2010free controls. Immunohistochemistry confirmed ZFPL1 co\u2010localization with NE and stem cell markers, suggesting an association with aggressive, androgen\u2010resistant PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ZFPL1 is a CT\u2010 and androgen\u2010regulated protein selectively expressed in malignant prostate cells and secreted via exosomes. Its elevated plasma levels and association with aggressive disease highlight its promise as a non\u2010invasive biomarker for PC detection and monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70148","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T22:09:36Z","timestamp":1773612576000},"page":"872-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosomal ZFPL1 Identifies Neuroendocrine and Stem Cell\u2010Like Prostate Cancer Subtypes?"],"prefix":"10.1002","volume":"86","author":[{"given":"Neshat","family":"Masud","sequence":"first","affiliation":[{"name":"Replace Louisiana for Los Angeles Pharmacology, University of Louisiana at Monroe Monroe Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnmesha","family":"Sanders","sequence":"additional","affiliation":[{"name":"Replace Louisiana for Los Angeles Pharmacology, University of Louisiana at Monroe Monroe Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Iczkowski","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, University of California Davis Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-4829","authenticated-orcid":false,"given":"Girish V.","family":"Shah","sequence":"additional","affiliation":[{"name":"Replace Louisiana for Los Angeles Pharmacology, University of Louisiana at Monroe Monroe Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32733published"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","unstructured":"S.Giona \u201cThe Epidemiology of Prostate Cancer \u201d inProstate Cancer(Exon Publications 2021) 1\u201316.","DOI":"10.36255\/exonpublications.prostatecancer.epidemiology.2021"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00072published"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-008-9139-6published"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.068published"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990210304"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65696-9"},{"issue":"3","key":"e_1_2_12_9_1","first-page":"320","article-title":"PSA Density and PSA Transition Zone Density in the Diagnosis of Prostate Cancer in PSA Gray Zone Cases","volume":"33","author":"Aksoy Y.","year":"2003","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"2","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-5347(01)65883-X","article-title":"Detection of Prostate Specific Antigen in Pancreas and Salivary Glands: A Potential Impact on Prostate Cancer Overestimation","volume":"156","author":"Elgamal A. 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