{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:51:04Z","timestamp":1791841864088,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the increasing integration of multiparametric MRI (mpMRI) and 68Ga\u2010PSMA PET\/CT into the diagnostic and staging algorithms of prostate cancer (PCa), digital rectal examination (DRE)\u2014a once foundational and cost\u2010effective physical examination\u2014has gradually become marginalized in daily clinical practice. However, the continued relevance of DRE in the modern imaging era remains uncertain. This study aimed to reassess the diagnostic value of DRE in the context of contemporary imaging tools, particularly mpMRI and PSMA PET\/CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included 164 patients diagnosed with prostate adenocarcinoma via transrectal ultrasound\u2010guided biopsy. All patients underwent DRE before biopsy, and 151 received mpMRI while 62 underwent PSMA PET\/CT. mpMRI findings were reported using PI\u2010RADS v2.1, and SUVmax values were recorded from PET\/CT reports. Radical prostatectomy was performed in 156 patients. The relationship between DRE findings and imaging parameters, biopsy results, and pathological staging was analyzed using multivariate statistics and ROC curve analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DRE findings were benign in 100 patients and suspicious for malignancy in 64. Suspicious DRE was significantly associated with higher PI\u2010RADS scores, greater lesion size, elevated SUVmax, and clinically significant PCa (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2009&lt;\u2009\u202f0.001 for all). Each one\u2010point increase in PI\u2010RADS was associated with a twofold rise in the likelihood of a positive DRE. ROC analyses identified a 13.5\u2009mm lesion size and an SUVmax of 15.1 as predictive thresholds for DRE positivity. Suspicious DRE also correlated with advanced pathological stage (\u2265\u2009pT3) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the rise of advanced imaging techniques, DRE remains a valuable adjunctive tool in identifying high\u2010risk and advanced PCa. When interpreted alongside mpMRI and PSMA PET\/CT findings, DRE provides additional clinical insight, supporting its continued role in risk stratification rather than screening in the modern diagnostic workflow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70151","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:48:16Z","timestamp":1772966896000},"page":"805-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In the Era of mpMRI and PSMA PET\/CT: Does Digital Rectal Examination Still Matter?"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-3336","authenticated-orcid":false,"given":"Anil","family":"Eker","sequence":"first","affiliation":[{"name":"Department of Urology Izmir City Hospital Izmir 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Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1547-5205","authenticated-orcid":false,"given":"Berk","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir City Hospital University of Health Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-292X","authenticated-orcid":false,"given":"Mahmut","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir City Hospital University of Health Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-4572","authenticated-orcid":false,"given":"Yasin","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Faculty of Medicine University of Health Sciences Izmir 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