{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:52:05Z","timestamp":1777945925361,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the effectiveness of triplet versus doublet therapy for time to castration\u2010resistant prostate cancer (CRPC) in Japanese patients with high\u2010volume metastatic hormone\u2010sensitive prostate cancer and examine Bayesian integration of external phase III trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed patients in the YUSHIMA registry with CHAARTED high\u2010volume metastatic hormone\u2010sensitive prostate cancer who started first\u2010line therapy between 2021 and 2024 and received triplet (androgen\u2010deprivation therapy\u2009+\u2009docetaxel\u2009+\u2009androgen receptor pathway inhibitor [ARPI];\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) or ARPI\u2010based doublet (androgen\u2010deprivation therapy\u2009+\u2009ARPI;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104). The primary endpoint was time to CRPC. Confounding was addressed using overlap weighting. Weighted Cox models and restricted mean survival time (RMST) were estimated at 12 and 24 months. An exploratory Bayesian power\u2010prior synthesis combined the YUSHIMA likelihood with reconstructed individual patient data from seven trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 23 months; 34 patients progressed to CRPC. Overlap\u2010weighted Cox analysis showed a statistically nonsignificant difference between triplet and doublet therapy (hazard ratio: 0.81, 95% confidence interval: 0.31\u20132.12). RMST differences (triplet minus doublet) were 0.21 months (95% confidence interval from \u22120.64 to 1.15) at 12 months and 0.95 months (95% confidence interval from \u22121.95 to 3.96) at 24 months. Bayesian synthesis analysis with borrowing strength\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.5 revealed posterior mean RMST differences of 1.42 and 3.19 months at 12 and 24 months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this propensity\u2010weighted registry analysis, triplet therapy was not demonstrably superior to ARPI\u2010based doublet therapy for time to CRPC. Exploratory Bayesian synthesis suggests a modest CRPC\u2010free RMST advantage with triplet therapy, but inferences depend on external evidence and remain hypothesis\u2010generating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70159","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:08:47Z","timestamp":1773947327000},"page":"911-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Comparison of Triplet Versus Doublet Therapy in Japanese Patients With High\u2010Volume Metastatic Hormone\u2010Sensitive Prostate Cancer: A Propensity\u2010Weighted Analysis From the YUSHIMA Registry and Exploratory Bayesian Evidence Synthesis"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-1680","authenticated-orcid":false,"given":"Yosuke","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8083","authenticated-orcid":false,"given":"Soichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugo","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Urology National Cancer Center Hospital East Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-0339","authenticated-orcid":false,"given":"Yoshitomo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-4527","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-2901","authenticated-orcid":false,"given":"Hajime","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-9887","authenticated-orcid":false,"given":"Hiroyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-7460","authenticated-orcid":false,"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics Institute of Science Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Urology Soka Municipal Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Yonese","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Red Cross Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tamiya","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Institute Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Urology Dokkyo Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama\u2010Nambu Chiiki Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-2489","authenticated-orcid":false,"given":"Yuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Urology Showa General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Toide","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Urology Kohnodai Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Urology JA Toride Medical Center Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Urology 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