{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:48:29Z","timestamp":1787971709865,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benign prostatic hyperplasia (BPH) is a common urologic condition in aging men, often linked to systemic inflammation and metabolic dysfunction. Emerging evidence suggests that the gut microbiome may contribute to prostate health and disease. Here we aim to explore potential associations between gut microbiota composition and clinical parameters, such as prostate volume (PV) and residual bladder volume (RBV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study analyzed stool samples from 28 patients undergoing transurethral surgery. Gut microbiota composition was analyzed using 16S rRNA gene sequencing. Patients were stratified into groups based on PV (\u2009\u2264\u200940\u2009mL vs. &gt;\u200940\u2009mL) and RBV (\u2009\u2264\u2009100\u2009mL vs. &gt;\u2009100\u2009mL). \u03b1\u2010diversity (Chao1 and Shannon indices) and \u03b2\u2010diversity (Jaccard distance) were calculated. Linear discriminant analysis effect size (LEfSe) was used to identify differentially abundant taxa between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences in gut microbial \u03b1\u2010 or \u03b2\u2010diversity were observed between groups stratified by PV or RBV. Nevertheless, several specific bacterial taxa showed significant variation between groups.\n                      <jats:italic>Methanobrevibacter smithii<\/jats:italic>\n                      was markedly less abundant in patients with PV\u2009&gt;\u200940\u2009mL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Similarly, patients with high RBV (\u2009\u2265\u2009100\u2009mL) exhibited distinct gut microbial profiles compared to those with lower RBV, characterized by a reduced abundance of\n                      <jats:italic>Collinsella<\/jats:italic>\n                      and an increased abundance of\n                      <jats:italic>Gastranaerophilales<\/jats:italic>\n                      (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that while overall gut microbial diversity may remain stable, specific taxa are associated with prostate and bladder phenotypes, supporting the concept of a gut\u2010prostate axis. Future research should focus on longitudinal studies to investigate how gut (and urinary) microbiota evolve alongside BPH and\/or LUTS over time, with the goal of determining whether microbial signatures could serve as early indicators for symptomatic BPH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70160","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:36:05Z","timestamp":1773862565000},"page":"900-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Gut\u2010Prostate Axis: Microbial Signatures Linked to Prostate Volume and Bladder Function"],"prefix":"10.1002","volume":"86","author":[{"given":"Jonathan","family":"Surber","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-7022","authenticated-orcid":false,"given":"Marie","family":"Lork","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scharl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Stephan","family":"Engeler","sequence":"additional","affiliation":[{"name":"Department of Urology Cantonal Hospital of St. Gallen, School of Medicine University of St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Langenauer","sequence":"additional","affiliation":[{"name":"Department of Urology Cantonal Hospital of St. Gallen, School of Medicine University of St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas John","family":"Hefermehl","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Urology, Kantonsspital Baden Baden Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Urology, Kantonsspital Baden Baden Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Hunziker","sequence":"additional","affiliation":[{"name":"Department of Urology Stadtspital Triemli Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Eberli","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-1458","authenticated-orcid":false,"given":"Uwe","family":"Bieri","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"},{"name":"Department of Surgery Division of Urology, Kantonsspital Baden Baden Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Poyet","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital of Zurich University of Zurich Zurich Switzerland"},{"name":"Department of Urology Stadtspital Triemli Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003698"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12745"},{"issue":"9","key":"e_1_2_11_4_1","first-page":"3","article-title":"Benign Prostatic Hyperplasia: An Overview","volume":"7","author":"Roehrborn C. 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