{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:50:37Z","timestamp":1793361037744,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As overall survival improves in metastatic hormone\u2010sensitive prostate cancer (mHSPC), non\u2010cancer causes of death are increasingly relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a real\u2010world multicenter study of patients diagnosed with mHSPC treated with ADT alone or in combination. Causes of death before progression to castration\u2010resistant prostate cancer (CRPC) were classified as cancer\u2010 or non\u2010cancer\u2010related. Deaths were classified as non\u2010cancer\u2010related if they occurred in the absence of cancer progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 565 patients, 35 (6.2%) died from non\u2010cancer\u2010related causes without disease progression, mainly infections (34%) and cardiovascular events (20%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010cancer mortality represents a meaningful proportion of deaths in mHSPC, supporting systematic cardiovascular risk evaluation and infection\u2010prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70174","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:27Z","timestamp":1777842327000},"page":"1170-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010Cancer Causes of Death in Patients With Metastatic Hormone\u2010Sensitive Prostate Cancer: A Real\u2010World Analysis"],"prefix":"10.1002","volume":"86","author":[{"given":"Marta","family":"Garcia de Herreros","sequence":"first","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ferrer\u2010Mileo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Fern\u00e1ndez\u2010Ma\u00f1as","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mases","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nely","family":"Diaz","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona 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Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Reig","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Figols","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fundaci\u00f3 Althaia Xarxa Assistencial Universit\u00e0ria de Manresa Manresa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Climent","sequence":"additional","affiliation":[{"name":"Medical Oncology Service Instituto Valenciano de Oncolog\u00eda (IVO) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Font","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Catal\u00e0 d'Oncologia Hospital Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Mellado","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Clinic Barcelona Spain"},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2010 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS) Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona 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