{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:08:24Z","timestamp":1778742504315,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Focal therapy (FT) encompasses ablation of the prostate cancer (PCa) while preserving the surrounding benign tissue, aiming to minimize or spare patients from postoperative complications. Although FT has been proven effective, the multifocal and heterogeneous nature of PCa is a significant concern regarding the risk of disease progression. The Genomic Prostate Score (GPS) has been shown to aid in the risk stratification of patients with localized disease; however, its role in patients undergoing FT remains unclear. We evaluated the association between the GPS performed on pretreatment biopsy cores and the oncological outcomes of patients with localized PCa treated with FT at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is an institutional review board\u2010approved retrospective review of a prospectively maintained database of PCa patients undergoing prostate FT at Duke between 2005 and 2020. The study included men with localized PCa, preoperative diagnostic prostate biopsy tissue availability, and a minimum follow\u2010up of 1\u2010year. The primary outcome was to evaluate the association between the GPS assay performed on the preoperative prostate biopsy tissue with cumulative incidence of treatment\u2010failure (TF) defined as requirement of salvage therapy and\/or development of metastasis, and prostate cancer\u2010specific death and failure\u2010free survival (FFS). The secondary outcome was to assess whether the GPS assay could predict \u2265 Gleason Grade Group (GGG) 2 biopsy recurrence\/persistence following ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 81 patients met the inclusion criteria. The median follow\u2010up was 48 months (IQR, 35\u201398). The median age, preoperative PSA, and PSA density were 74 years (IQR, 68\u201377), 7.4\u2009ng\/ml (IQR, 5.5\u201310), and 0.19\u2009ng\/mL\/mL (0.14\u20130.22), respectively. Of 81 patients, 55 (68%) and 7 (9%) had intermediate and high\u2010risk disease. The median GPS score was 30 (IQR, 24\u201340), and 21\/81 (26%) had a GPS result &gt;\u200940. TF and \u2265\u2009GGG2 biopsy recurrence were observed in 15\/81 (19%) and 10\/81 (12%), respectively. GPS was &gt;\u200940 in 8\/15 (53%) and 7\/10 (70%) of patients with TF and biopsy recurrence, respectively. On univariable analysis, GPS was significantly associated with TF (HR 1.07, 95%\u2009CI, 1.02\u20131.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and biopsy recurrence\/persistence (HR 1.09, 95% CI, 1.03\u20131.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). Men with GPS of 40\u2013100 were found to be significantly at higher risk of having TF (HR 4.19, 95% CI, 1.26\u201313.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and in\u2010field biopsy recurrence (HR 14.3, 95% CI, 2.48\u201382.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among men treated with focal ablation for localized PCa, the GPS assay appears to be a prognostic indicator of FFS and GGG\u2009\u2265\u20092 biopsy recurrence. Further studies with large sample sizes are required to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70175","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:25:05Z","timestamp":1775672705000},"page":"1006-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Prostate Score (GPS) as a Prognostic Biomarker in Patients With Localized Prostate Cancer Undergoing Focal Therapy"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-9558","authenticated-orcid":false,"given":"Sriram","family":"Deivasigamani","sequence":"first","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-9102","authenticated-orcid":false,"given":"Srinath","family":"Kotamarti","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-5658","authenticated-orcid":false,"given":"Mahdi","family":"Mottaghi","sequence":"additional","affiliation":[{"name":"IMR, Veteran Affairs Medical System Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-1973","authenticated-orcid":false,"given":"Eric S.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Ghoreifi","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-774X","authenticated-orcid":false,"given":"Denis","family":"Seguier","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Urology Lille University Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Ivey","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao Paulo","family":"Zambon","sequence":"additional","affiliation":[{"name":"MDX Health Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Podichetty","sequence":"additional","affiliation":[{"name":"MDX Health Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy","family":"Can","sequence":"additional","affiliation":[{"name":"Exact Sciences Corporation Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Groshopf","sequence":"additional","affiliation":[{"name":"MDX Health Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan T.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judd.W","family":"Moul","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Anesthesiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-1372","authenticated-orcid":false,"given":"Thomas J.","family":"Polascik","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Duke University Medical Center Durham North Carolina USA"},{"name":"IMR, Veteran Affairs Medical System Durham North Carolina USA"},{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0740"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.12.030"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.01.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230160"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.23736\/s2724-6051.20.04160-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2023.04.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0063"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-019-0526-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-690"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.05.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.09.013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/po-25-00535"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110929"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.033"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.06.1126"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.04.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.027"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2363-y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.05.045"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00376-7"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:19:04Z","timestamp":1778739544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/pros.70175"],"URL":"https:\/\/doi.org\/10.1002\/pros.70175","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}