{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:55:26Z","timestamp":1781592926299,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypofractionated salvage radiotherapy is increasingly used for biochemical recurrence of prostate cancer post\u2010prostatectomy, yet its toxicity profile remains underexplored. This study evaluates the incidence, timing, and resolution of treatment\u2010related toxicities in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of 403 men receiving hypofractionated salvage radiotherapy (62.5\u2009Gy in 25 fractions) from 2017 to 2024 was conducted. Toxicities, categorized as genitourinary (hematuria, urinary incontinence, frequency, dysuria) or gastrointestinal (rectal bleeding, diarrhea, proctitis, nausea), were graded (1\u20133) using CTCAE\u2010based criteria. Outcomes included any\u2010time incidence, Kaplan\u2013Meier time\u2010to\u2010first\u2010event estimates (12\u2010 and 24\u2010month cumulative incidence), and first\u2010onset timing. Episode\u2010level analyses merged events \u2264\u200930 days apart, assessing resolution and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow\u2010up was 18.2 months. Any\u2010grade genitourinary and gastrointestinal toxicities occurred in 34.2% and 24.6% of patients, respectively (24\u2010month incidence: genitourinary 40.4%; gastrointestinal 28.9%). Grade 2+ toxicities were less frequent (genitourinary 9.7%; gastrointestinal 7.7%), with Grade 3+ rare (genitourinary 1.7%; gastrointestinal 0.7%). In terms of patient\u2010level ever\u2010event incidences, common symptoms included urinary incontinence (20.3%), rectal bleeding (19.9%), and hematuria (13.9%). Urinary toxicities predominantly onset at 6\u201312 months, whereas rectal bleeding and hematuria emerged later (\u2265\u200912 months). Approximately two\u2010thirds of Grade 2+ episodes resolved (e.g., urinary incontinence, 66.7%; rectal bleeding, 69.2%), with median resolution times of 3.0\u20138.4 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With a median follow\u2010up of 18.2 months, hypofractionated salvage radiotherapy demonstrates favorable short\u2010to\u2010intermediate term tolerability, with infrequent severe toxicities. Vigilant monitoring for late\u2010onset rectal bleeding and hematuria is recommended during the 6\u201324 months after treatment to optimize patient management. Longer follow\u2010up is required to confirm long\u2010term safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70178","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:28Z","timestamp":1777842328000},"page":"1115-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Patterns and Resolution of Toxicities Following Hypofractionated Salvage Radiotherapy for Biochemical Recurrence of Prostate Cancer After Prostatectomy"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-9855","authenticated-orcid":false,"given":"Bum\u2010Sup","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Seoul National University College of Medicine, Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Joo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Dongguk University Ilsan Hospital, Dongguk University College of Medicine Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University College of Medicine, Seoul National University Hospital Seoul Korea"},{"name":"Medical Research Center, Institute of Radiation Medicine Seoul National University Seoul 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