{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:38:51Z","timestamp":1790289531401,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Previous studies have demonstrated an association between PSMA\u2010PET SUVmax and poorer survival outcomes in patients with mCRPC. However, limited data are available in mHSPC. We aim to investigate the relationship between baseline PSMA\u2010PET SUVmax and rPFS in patients with mHSPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The optimal SUVmax cut\u2010off for rPFS was determined using Harrell's C\u2010index. Baseline characteristics were compared using the\n                      <jats:italic>\u03c7<\/jats:italic>\n                      \u00b2 test between the groups and survival analyses for rPFS were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 165 patients were retrospectively analyzed, with a median follow\u2010up of 44 months (mo) (range: 9\u2013103 mo). A total of 17.16 was identified as the optimal SUVmax cutoff. Baseline characteristics were compared whit this threshold. SUVmax higher patients showed poor ECOG PS, high denovo metastases, high volume, higher ALP, and high median PSA level. The median rPFS for the entire cohort was 34.3 mo (95% CI: 22.0\u201346.5 mo). In univariate analysis, patients with higher SUVmax had a median rPFS of 23 mo versus 60.4 mo in those with low SUVmax (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2009&lt;\u2009\u202f0.001). ALP normal versus higher (41.5 vs. 20.7 mo,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), hemoglobin &lt;\u200912\u2009g\/dL versus \u2265\u200912\u2009g\/dL (21.2 vs. 48.4 mo,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), low versus high tumor volume (60.4 vs. 23 mo,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and PSA \u2265\u200935\u2009ng\/mL versus PSA\u2009&lt;\u200935\u2009ng\/mL (23.9 mo vs NR,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). Furthermore, patients not receiving ARPIs therapy exhibited inferior rPFS (ADT\u2010alone:20.7 mo vs. ADT + docetaxel:19.2 mo vs. ADT plus ARPIs: 48.4 mo,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated that high SUVmax has a negative prognostic impact on rPFS in mHSPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70185","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:33:32Z","timestamp":1776879212000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Clinical Significance of Gallium\u201068 PSMA\u201011 PET\u2010Derived SUVmax in the Management of Metastatic Hormone\u2010Sensitive Prostate Cancer"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-9988","authenticated-orcid":false,"given":"Cevat \u0130lteri\u015f","family":"K\u0131k\u0131l\u0131","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Kapar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Bak\u0131rk\u00f6y Sadi Konuk Training and Research Hospital Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyyaz Hazar","family":"Ya\u011fmur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Istanbul Education and Research Hospital Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-6393","authenticated-orcid":false,"given":"Bahad\u0131r","family":"K\u00f6yl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Kemik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu\u011fra Han","family":"Esen","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ko\u00e7 University School of Medicine Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-3150","authenticated-orcid":false,"given":"\u0130lkay","family":"G\u00fclt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Istanbul Education and Research Hospital Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Bak\u0131rk\u00f6y Sadi Konuk Training and Research Hospital Istabul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Sel\u00e7ukbiricik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ko\u00e7 University School of Medicine Istabul 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