{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:04:23Z","timestamp":1790438663832,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early deep prostate\u2010specific antigen (PSA) decline after the initiation of androgen receptor signaling inhibitor (ARSI) therapy is associated with favorable long\u2010term outcomes in metastatic castration\u2010sensitive prostate cancer (mCSPC). The Nadir ARSI\u2010Derived Integrative Response (NADIR) model was recently developed using Phase III trial data to predict the probability of achieving a favorable early PSA response. However, its performance in real\u2010world clinical settings remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 196 patients with mCSPC who received first\u2010line ARSI therapy at Hiroshima University Hospital and affiliated institutions between 2018 and 2025; 186 had complete data required to calculate the NADIR score. An early favorable PSA response was defined as a decline in PSA to \u2264\u20090.2\u2009ng\/mL within 6 months of treatment initiation. Model discrimination was assessed using the area under the receiver operating characteristic curve (AUC), and calibration was evaluated using calibration plots. Patients were stratified into tertiles based on the NADIR score, and time\u2010to\u2010event outcomes, including overall survival (OS) and time to castration\u2010resistant prostate cancer (CRPC), were analyzed using the Kaplan\u2013Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of patients with an early favorable PSA response decreased stepwise across the upper, middle, and lower tertiles (61.3%, 33.8%, and 17.7%, respectively; Cochran\u2013Armitage trend test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The NADIR model demonstrated acceptable discrimination for predicting an early favorable PSA response, with an AUC of 0.74 (95% confidence interval [CI] 0.66\u20130.81). Agreement between predicted probabilities and observed outcomes was maintained across NADIR\u2010defined risk groups. In a univariable analysis treating the NADIR score as a continuous variable, higher NADIR scores were strongly associated with an early favorable PSA response (odds ratio per 10% increase, 1.74; 95% CI 1.36\u20132.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CRPC\u2010free survival differed significantly across NADIR\u2010defined tertiles, whereas OS did not differ significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, the NADIR model retained acceptable predictive performance, suggesting applicability in routine clinical practice and potential utility in individualized pretreatment clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70186","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:31:24Z","timestamp":1776879084000},"page":"1053-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of the Nadir Androgen Receptor Signaling Inhibitor\u2010Derived Integrative Response Model in Real\u2010World Patients With Metastatic Castration\u2010Sensitive Prostate Cancer"],"prefix":"10.1002","volume":"86","author":[{"given":"Kazuma","family":"Yukihiro","sequence":"first","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Sekino","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-9479","authenticated-orcid":false,"given":"Kohei","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Miyoshi Central Hospital Miyoshi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Fujiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Asa Citizens Hospital Hiroshima Japan"},{"name":"Department of Urology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Kagiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Matsuyama Red Cross Hospital Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kurimura","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-0614","authenticated-orcid":false,"given":"Kenichiro","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Urology NHO Kure Medical Center and Chugoku Cancer Center Kure Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-0751","authenticated-orcid":false,"given":"Miki","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-115X","authenticated-orcid":false,"given":"Shunsuke","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-3916","authenticated-orcid":false,"given":"Kohei","family":"Kobatake","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical Sciences Hiroshima 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