{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:28Z","timestamp":1786978408973,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The clinical relevance of HER2 expression profile in solid cancers has expanded with the evolving landscape of HER2 targeting agents. This systematic review and meta\u2010analysis aim to detail the prevalence of HER (over)expression in prostate cancer and identify patient\/disease subgroups with enriched HER2 overexpression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Literature searches of five databases were performed. HER2 scores with cross\u2010tabulation of clinicopathological parameters were extracted for pooled prevalence and odds ratio analyses. Study quality, heterogeneity, and publication bias were assessed by the CASP checklist,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      index, and LFK index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 16 studies were included with 1258 cases. There were 669 (53.18%), 269 (21.38%), 250 (19.87%), and 70 (5.56%) of HER2 Scores 0\/1\/2\/3, respectively. Pooled analysis indicated a prevalence of 4.9% (95% CI 3.0%\u20137.2%) for HER2 Score 3 and 42.0% (95% CI 29.0%\u201355.6%) for HER2 non\u2010negative (Scores 1\u20133). Subgroup analysis comparing HER2 negative (0, 1) and HER2 overexpression (3) indicated higher Gleason score (OR\u2009=\u20090.061, 95% CI: 0.010\u20130.359,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), higher disease stage (OR\u2009=\u20090.063, 95% CI: 0.016\u20130.252,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and biopsies from metastatic site (OR: &gt;\u2009100, 95% C.I.: &gt;\u2009100\u2013&gt;\u2009100,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) favoring HER overexpression, without significant differences for patient age or prostate\u2010specific antigen (PSA) level.\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      was 91.63% with meta\u2010regression analysis showing study quality as a source of heterogeneity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). LFK index was 1.93 (moderate publication bias risk,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.054).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HER2 overexpression is rare in prostatic carcinomas but nearly half show HER2 expression of Score 1 or above. Cases with higher Gleason score and advanced disease stage are more likely to overexpress HER2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70187","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:28:59Z","timestamp":1776878939000},"page":"1061-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human Epidermal Growth Factor Receptor 2 Expression in Prostatic Carcinomas: A Systematic Review and Meta\u2010Analysis of a Potential Therapeutic Target"],"prefix":"10.1002","volume":"86","author":[{"given":"Jacky T. F.","family":"Luk","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther K. C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renald","family":"Me\u00e7ani","sequence":"additional","affiliation":[{"name":"Epistudia Bern Switzerland"},{"name":"Department of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-3073","authenticated-orcid":false,"given":"Taulant","family":"Muka","sequence":"additional","affiliation":[{"name":"Epistudia Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Nano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, TUM School of Medicine and Health, Klinikum Rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna K. M.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K. L.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Mary Hospital The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C. W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen Mary Hospital The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0314","authenticated-orcid":false,"given":"Joshua J. X.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20065"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-021-00265-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00140-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00576-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/phrs.2023.1605454"},{"key":"e_1_2_10_7_1","unstructured":"\u201cCASP Checklist: For Descriptive\/Cross\u2010Sectional Studies \u201d (2024).https:\/\/casp-uk.net\/casp-tools-checklists\/."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000141"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-025-02527-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2007.55"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2649-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"e_1_2_10_13_1","first-page":"2825","article-title":"Scikit\u2010Learn: Machine Learning in Python","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.25080\/Majora-92bf1922-011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.25080\/Majora-92bf1922-00a"},{"key":"e_1_2_10_16_1","author":"Yarkoni T.","year":"2021","journal-title":"PyMARE: Python Meta\u2010Analysis & Regression Engine"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_361_23"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152219"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4274\/cjms.2021.2021-117"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2347"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5152\/etd.2014.8157"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.15.6425"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21252"},{"issue":"24","key":"e_1_2_10_24_1","first-page":"4345","article-title":"Prognostic Value of Her\u20102\/neu and Clinicopathologic Factors for Evaluating Progression and Disease\u2010Specific Death in Chinese Men With Prostate Cancer","volume":"124","author":"Zhang Y. 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