{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:08:13Z","timestamp":1778742493719,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic nonurological complications are common among prostate cancer (PCa) survivors; however, their spectrum, magnitude, and genetic contribution remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated 15 commonly reported nonurological complications and tested their associations with exposure to PCa and disease\u2010specific polygenic risk scores (PRS) in the UK Biobank (UKB;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009219,133). Analyses were conducted using cause\u2010specific Cox proportional\u2010hazards models within a full\u2010cohort framework with time\u2010updated PCa status, delayed entry at study recruitment, and age as the underlying time scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After recruitment, incident PCa was diagnosed in 13,780 men, of which 1,656 (12.02%) had metastatic PCa (mPCa). Risks for seven complications were higher among men with PCa, adjusting for genetic background (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), including osteoporosis, venous thromboembolism, depression, and four primary cancers (bladder, kidney, colorectal, and pancreatic). Risks were consistently stronger among men exposed to mPCa than non\u2010mPCa; for example, the hazard ratio (HR) (95% confidence interval) for osteoporosis was 1.88 (1.63\u20132.18) for any PCa, 4.67 (3.11\u20137.01) for mPCa, and 1.75 (1.50\u20132.04) for non\u2010mPCa. Elevated risks for three additional complications (coronary artery disease, type 2 diabetes and chronic obstructive pulmonary disease) were observed only among men with mPCa. The risks for these ten complications were further increased among men with higher disease\u2010specific PRS; for example, the HR for osteoperosis in mPCa patients in the top PRS quartile was 13.57 (8.24\u201322.34) compared with men without PCa (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCa diagnosis and inherited genetic susceptibility jointly contribute to increased risks of multiple chronic non\u2010urological complications among survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70190","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:50:41Z","timestamp":1777470641000},"page":"1083-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non\u2010Urological Complications"],"prefix":"10.1002","volume":"86","author":[{"given":"Brian T.","family":"Helfand","sequence":"first","affiliation":[{"name":"Division of Urology, Endeavor Health Evanston Illinois USA"},{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"},{"name":"Section of Urology, Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley J.","family":"Mulford","sequence":"additional","affiliation":[{"name":"Genomic Health Initiative, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy","family":"Tran","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Lilly","family":"Zheng","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA"},{"name":"Genomic Health Initiative, Endeavor Health Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Graham","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-1415","authenticated-orcid":false,"given":"Joshua","family":"Cabral","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Lu","sequence":"additional","affiliation":[{"name":"GoPath Diagnostics Buffalo Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Beebe\u2010Dimmer","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Cooney","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Duke Cancer Institute Duke University School of Medicine Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Duggan","sequence":"additional","affiliation":[{"name":"Translational Genomics Research Institute, Part of City of Hope Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-8752","authenticated-orcid":false,"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Urology, Endeavor Health Evanston Illinois USA"},{"name":"Program for Genomic Translational Research, Endeavor Health Evanston Illinois USA"},{"name":"Section of Urology, Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33584"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8145173"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.19568"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu103"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214122"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21234"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70606-5"},{"key":"e_1_2_10_12_1","article-title":"Does Race\/Ethnicity Affect Secondary Bladder and Rectal Cancer Rates After Prostate Cancer Radiation? 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