{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:55:36Z","timestamp":1781592936727,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Local recurrence after definitive radiotherapy for prostate cancer (PCa) remains a challenging clinical problem. Salvage irreversible electroporation (sIRE) is a non\u2010thermal focal ablation approach with limited published evidence in the radiorecurrent setting. We report safety and early oncologic outcomes of sIRE for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of consecutive patients undergoing sIRE at a single institution (December 2023 to June 2025). Inclusion required biopsy\u2010confirmed intraprostatic recurrence and PSMA PET demonstrating no metastatic disease. Outcomes included perioperative morbidity, early PSA response, and post\u2010treatment prostate MRI findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen patients underwent sIRE. Mean age was 73.78\u2009\u00b1\u20097.0 years. Seventeen patients were discharged on the day of surgery. Postoperative urinary morbidity included urinary tract infection in 3 patients (16.7%), urinary retention requiring limited TURP in 2 (11.1%), and new bothersome storage lower urinary tract symptoms requiring treatment in 2 (11.1%). Mean PSA decreased from 5.37\u2009\u00b1\u20092.09\u2009ng\/mL pre\u2010IRE to 1.61\u2009\u00b1\u20091.57\u2009ng\/mL at approximately 3 months, and 2.17\u2009\u00b1\u20091.92\u2009ng\/mL at approximately 6 months. Twelve patients underwent post\u2010IRE prostate MRI; results included post\u2010treatment change, or ablation defect, or susceptibility artifact in most patients. One patient underwent repeat PSMA PET for a rising PSA and was found to have a PSMA\u2010avid lung lesion consistent with metastatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salvage IRE for radiorecurrent prostate cancer has generally manageable short\u2010term urinary morbidity and encouraging early PSA responses, with limited utility of post\u2010treatment MRI. A longer follow\u2010up is needed to define durability and optimal selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70193","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:30Z","timestamp":1777842330000},"page":"1150-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Safety and Early Oncologic Outcomes of Salvage Irreversible Electroporation for Radiorecurrent Prostate Cancer"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0356-9636","authenticated-orcid":false,"given":"Jarrett","family":"Noakes","sequence":"first","affiliation":[{"name":"Department of Urology The Warren Alpert Medical School of Brown University Providence Rhode Island USA"},{"name":"Minimally Invasive Urology Institute at The Miriam Hospital Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Department of Urology The Warren Alpert Medical School of Brown University Providence Rhode Island USA"},{"name":"Minimally Invasive Urology Institute at The Miriam Hospital Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Hyams","sequence":"additional","affiliation":[{"name":"Department of Urology The Warren Alpert Medical School of Brown University Providence Rhode Island USA"},{"name":"Minimally Invasive Urology Institute at The Miriam Hospital Providence Rhode Island 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