{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:22Z","timestamp":1786978342788,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201018\u20101\u20100618"],"award-info":[{"award-number":["W81XWH\u201018\u20101\u20100618"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201019\u20101\u20100720"],"award-info":[{"award-number":["W81XWH\u201019\u20101\u20100720"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ethnicity and pathological factors contribute to differences in prostate neoplasm, and this landscape could be influenced by the local microbiome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate whether prostate tissue harbors race\u2010specific microbiota, we performed 16S rRNA gene sequencing of various hypervariable regions of cancer, inflammation, and non\u2010cancer (benign) tissue from Black and White American men with prostate cancer followed by qRT\u2010PCR for validation. All reported p\u2010values were adjusted for false discovery rate to account for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Comparative analysis revealed marked differences in microbial composition between the two groups. Several species showed significant differential abundance, including\n                      <jats:italic>Alphaproteobacteria<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>Bacteroides fragilis<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>Candidatus Kerfeldbacteria<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>Flavobacterium frigoris<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001),\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.003),\n                      <jats:italic>Rhizobiales bacterium<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001),\n                      <jats:italic>Sphingomonas glacialis<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Lesion\u2010specific analysis further identified\n                      <jats:italic>Pseudomonadota<\/jats:italic>\n                      ,\n                      <jats:italic>Actinomycetota<\/jats:italic>\n                      , and\n                      <jats:italic>Bacilliota<\/jats:italic>\n                      as the most abundant phyla in inflammatory lesions of both racial groups. However,\n                      <jats:italic>Tenericutes<\/jats:italic>\n                      were uniquely present in Black American samples, whereas\n                      <jats:italic>Bacteroidota<\/jats:italic>\n                      and\n                      <jats:italic>Deinococcota<\/jats:italic>\n                      were more abundant in the inflammatory lesions of White American men. At the genus level, analysis identified several key bacterial taxa associated with prostate cancer.\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Abiotrophia<\/jats:italic>\n                      , and\n                      <jats:italic>Acinetobacter<\/jats:italic>\n                      were significantly enriched in the Black American prostate tissues, while\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      and\n                      <jats:italic>Corynebacterium<\/jats:italic>\n                      were more abundant in tissue from White American men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to demonstrate significant microbial diversity and distinct microbial signatures in Black and White American men, suggesting that intra\u2010prostatic bacteria may play a role in disease disparities and pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70200","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T18:12:13Z","timestamp":1779819133000},"page":"1202-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbial Differences in Prostate Lesions Between Black and White American Men"],"prefix":"10.1002","volume":"86","author":[{"given":"Shiv","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Urology Case Western Reserve University Cleveland Ohio USA"},{"name":"The Urology Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Urology Case Western Reserve University Cleveland Ohio USA"},{"name":"The Urology Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-2042","authenticated-orcid":false,"given":"Gregory T.","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University Cleveland Ohio 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