{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:45:33Z","timestamp":1785678333225,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (&lt;\u20095% vs. &gt;\u20095%) in the resected tissue. We tested for other models that could improve cancer\u2010specific survival (CSS) predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Incidental (cT1a\/cT1b) PCa patients were retrospectively identified within the Surveillance, Epidemiology, and End Results (SEER) database (2004\u20132015). Kaplan\u2013Meier plots illustrated CSS at 5 years of follow\u2010up. Combination of variables resulted in three distinct stratification models based on cT1a vs. cT1b and Gleason score sum (GS). Multivariable Cox regression models that predicted CSS were used for area under the curve (AUC) quantification after 20\u2010fold cross validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified a total of 5155 incidental PCa patients. CSS at 5 years was 98% for cT1a vs. 90% for cT1b (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). CSS at 5 years for combination of cT1a and GS 6 patients was 99% vs. 92% for patients with either cT1b or GS\u2009\u2265\u20097 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Finally, for patients with GS\u2009&lt;\u20098, CSS at 5 years was 98% vs. 72% for patients with GS\u2009\u2265\u20098 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The multivariable adjusted AUC was 0.83 vs. 0.82 vs. 0.88, for each model, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Of all tested stratification models, the consideration of GS stratified between &lt;\u20098 and \u2265\u20098 resulted in the best survival discrimination, as well as highest accuracy after cross\u2010validation. In consequence, the use of this model (GS\u2009&lt;\u20098 vs. \u2265\u20098) appears better suited than the standard cT1a vs. cT1b substaging, when CSS represents the endpoint of interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70221","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:06:03Z","timestamp":1785675963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparisons of Novel Risk Stratification Models to the Current cT1a\/b Staging in Incidental Prostate Cancer"],"prefix":"10.1002","author":[{"given":"Lukas","family":"Scheipner","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia Maria Ippolita","family":"Jannello","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IEO European Institute of Oncology, IRCCS Milan Italy"},{"name":"Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Siech","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario de","family":"Angelis","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology, Urological Research Institute, IRCCS San Raffaele Scientific Institute Comprehensive Cancer Center Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Di","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology University of Naples \u201cFederico II\u201d Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Weill Cornell Medical College New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Dallas Texas USA"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Research Institute, IRCCS San Raffaele Scientific Institute Comprehensive Cancer Center Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K. H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Research Institute, IRCCS San Raffaele Scientific Institute Comprehensive Cancer Center Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Carmignani","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano Milan Italy"},{"name":"Department of Urology IRCCS Ospedale Galeazzi \u2010 Sant'Ambrogio Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio De","family":"Cobelli","sequence":"additional","affiliation":[{"name":"Department of Urology IEO European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Oncology and Haemato\u2010Oncology Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3394-0596","authenticated-orcid":false,"given":"Nicola","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology University of Naples \u201cFederico II\u201d Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Mischinger","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Ahyai","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURURO.2020.09.042"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.03.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0B013E328344E4AD"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.03.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EURURO.2011.03.012"},{"key":"e_1_2_11_7_1","unstructured":"SEER Cause of Death Recode Accessed June 12 2023.https:\/\/seer.cancer.gov\/codrecode\/."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.0006-341X.2000.00337.X"},{"key":"e_1_2_11_9_1","unstructured":"R: The R Project for Statistical Computing Accessed June 4 2023 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Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:06:04Z","timestamp":1785675964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":15,"alternative-id":["10.1002\/pros.70221"],"URL":"https:\/\/doi.org\/10.1002\/pros.70221","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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