{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:16Z","timestamp":1789168516108,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is unknown how survival is prematurely curtailed by incidental prostate cancer (IPCa). We aimed to quantify the average years of life lost (YLL) due to IPCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within the SEER database 2004\u20132021, IPCa patients aged 45\u201375 were identified. Stratification was based on the Gleason sum, clinical stage, and active treatment (radical prostatectomy or radiotherapy) status. Monte Carlo simulated individual survival according to the Social Security Administration life tables. Subsequently, YLL was compared between IPCa patients versus controls using the Kaplan\u2010Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 7324 IPCa patients, 1926 (26.7%) and 5398 (73.7%) received active treatment or no active treatment, respectively. Compared to population controls, IPCa patients exhibited a survival disadvantage of 0.23 YLL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients without active treatment exhibited a larger survival disadvantage of 0.25 YLL, compared to patients with active treatment (0.18 YLL). In subgroup analyses, the largest YLL disadvantage was observed in patients not receiving active treatment with Gleason sum 8\u201310 (2.67 YLL), clinical stage T1b (0.83 YLL), and both (Gleason sum 8\u201310, T1b: 3.02 YLL). Conversely, in active treatment patients with Gleason sum \u2264\u20097 and\/or T1a, no YLL disadvantage was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IPCa patients with advanced Gleason sum or clinical stage exhibited substantial YLL disadvantages, when they did not benefit from active treatment. Therefore, these patients should receive active treatment. Conversely, omitting active treatment in low\u2010risk IPCa patients did not impact premature death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70222","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:46:54Z","timestamp":1783540014000},"page":"1375-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Years of Life Lost in Incidental Prostate Cancer"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-3982","authenticated-orcid":false,"given":"Fabian","family":"Falkenbach","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Martini\u2010Klinik Prostate Cancer Center University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Department of Urology University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Longoni","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marmiroli","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Department of Urology IEO European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Oncology and Haemato\u2010Oncology Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh","family":"Chi Le","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Department of Urology, Goethe University Frankfurt University Hospital Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6265-5288","authenticated-orcid":false,"given":"Calogero","family":"Catanzaro","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Department of Urology University of Bologna, St. Orsola\u2010Malpighi Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7773-5101","authenticated-orcid":false,"given":"Michele","family":"Nicolazzini","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Department of Translational Medicine, Division of Urology, University of Eastern Piedmont Maggiore della Carit\u00e0 Hospita Novara Italy"},{"name":"Department of Oncology, Division of Urology University of Turin Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Polverino","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples 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H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology, Goethe University Frankfurt University Hospital Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer 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