{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:01:08Z","timestamp":1790755268478,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stereotactic ablative radiotherapy (SABR) is emerging as an alternative treatment for patients with locally recurrent prostate cancer after previous radiation. This approach allows for precise target coverage while limiting toxicity to surrounding organs. However, reported outcomes following re\u2010irradiation of the prostate with SABR remain variable. This systematic review and meta\u2010analysis therefore evaluated the efficacy and toxicity of prostate re\u2010irradiation with SABR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta\u2010analysis compliant with PRISMA guidelines was conducted to evaluate studies of SABR for local re\u2010irradiation of prostate cancer. Random\u2010effects models were employed to pool biochemical recurrence\u2010free survival (BRFS), local relapse\u2010free survival (LRFS), metastasis\u2010free survival (MFS), and gastrointestinal (GI) and genitourinary (GU) toxicities after SABR re\u2010irradiation. Outcomes were pooled as proportions using the Freeman\u2013Tukey double arcsine transformation, and heterogeneity was assessed using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      . Statistical analyses were performed using Stata version 19.5.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 treatment cohorts from 29 studies, including 1099 patients, were analysed. The pooled rates for 2\u2010year BRFS, LRFS, and MFS were 62.5% (95% CI, 54.1\u201370.6%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200981.9%), 89.9% (95% CI, 80.6\u201396.5%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200985.5%), and 84.6% (95% CI, 77.3\u201390.7%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200977.8%), respectively. Acute severe side effects were rare, with pooled rates of grade 3\u20134 GI toxicities of 0.7% (95% CI, 0.3\u20131.4%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) and grade 3\u20134 GU toxicities of 1.1% (95% CI, 0.6%\u20131.9%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Late grade 3\u20134 toxicity also remained low, with pooled GI and GU rates of 1.0% (95% CI, 0.5\u20131.7%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) and 3.3% (95% CI, 2.0\u20135.0%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200946.1%), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prostate re\u2010irradiation with SABR is associated with favourable short\u2010 and intermediate\u2010term oncologic outcomes, including high local control and metastasis\u2010free survival, with acceptable toxicity. The heterogeneity observed across studies and the very low certainty of evidence encourage the inclusion of these patients in prospective trials or registries to improve patient selection, dose\u2013fractionation strategies, and long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70233","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:55:47Z","timestamp":1787511347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereotactic Prostate Cancer Ablative Re\u2010Irradiation: A Systematic Review and Meta\u2010Analysis (SPARE)"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-3557","authenticated-orcid":false,"given":"Andre G.","family":"Gouveia","sequence":"first","affiliation":[{"name":"McMaster University Hamilton Canada"},{"name":"The University of British Columbia Vancouver Canada"},{"name":"Latin America Cooperative Oncology Group (LACOG) Porto Alegre Brazil"},{"name":"Department of Radiation Oncology, BC Cancer Centre for the North, Prince George  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8879-9759","authenticated-orcid":false,"given":"Jody","family":"Tao","sequence":"additional","affiliation":[{"name":"The University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-0882","authenticated-orcid":false,"given":"Gregory","family":"Pond","sequence":"additional","affiliation":[{"name":"McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4721-5196","authenticated-orcid":false,"given":"Kevin","family":"Dong","sequence":"additional","affiliation":[{"name":"The University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-5218","authenticated-orcid":false,"given":"Allison","family":"Ye","sequence":"additional","affiliation":[{"name":"The University of British Columbia Vancouver Canada"},{"name":"Department of Radiation Oncology, BC Cancer Centre for the North, Prince George  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-832X","authenticated-orcid":false,"given":"Arthur A.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Latin America Cooperative Oncology Group (LACOG) Porto Alegre Brazil"},{"name":"Radiotherapy Department Hospital Santa Izabel Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Palhares","sequence":"additional","affiliation":[{"name":"McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad J. Q.","family":"Villafuerte","sequence":"additional","affiliation":[{"name":"Ateneo School of Medicine and Public Health Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Anselmo","sequence":"additional","affiliation":[{"name":"Radiotherapy Oncology Centre, \u201cS. Maria\u201d Hospital Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-9215","authenticated-orcid":false,"given":"Fabio Y.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Latin America Cooperative Oncology Group (LACOG) Porto Alegre Brazil"},{"name":"Queen's University Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Radiotherapy Oncology Centre, \u201cS. Maria\u201d Hospital Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-6197","authenticated-orcid":false,"given":"Robert","family":"Olson","sequence":"additional","affiliation":[{"name":"The University of British Columbia Vancouver Canada"},{"name":"Department of Radiation Oncology, BC Cancer Centre for the North, Prince George  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Tsakiridis","sequence":"additional","affiliation":[{"name":"McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.054"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00855"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.01.049"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173883"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24470"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.01.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2024.100806"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00883-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102206"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0522"},{"key":"e_1_2_11_14_1","unstructured":"A.Rohatgi \u201cWebPlotDigitizer [software] \u201d Version 4.6. 2024 https:\/\/automeris.io\/WebPlotDigitizer."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2016.03.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-017-0789-9"},{"issue":"9","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/S1569-9056(17)31769-4","article-title":"Role of [11C] Choline Pet\/Ct for Salvage Focal Cyberknife Hypofractionated Stereotactic Radiotherapy","volume":"16","author":"Bossi Zanetti I.","year":"2017","journal-title":"European Urology Supplements"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00071"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjro.20180027"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8120536"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.541"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.10.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2020.03.009"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13303"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2020_200622N651"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.858740"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133187"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24511"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.6_suppl.365"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-023-02043-3"},{"issue":"1","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"S1215","DOI":"10.1016\/S0167-8140(23)66412-6","article-title":"MRgSBRT Reirradiation in Locally Recurrent Prostate Cancer: A Multicentric Retrospective Analysis","volume":"182","author":"D'Aviero A.","year":"2023","journal-title":"Radiotherapy and Oncology"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-023-01721-7"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2023.01.007"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.01.009"},{"issue":"1","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"S1205","DOI":"10.1016\/S0167-8140(23)66403-5","article-title":"PO\u20101488 Local Recurrence of Prostate Cancer After Curative RT: The Role of Salvage SBRT Re\u2010Irradiation","volume":"182","author":"Sigillo R. C.","year":"2023","journal-title":"Radiotherapy and Oncology"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01391"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111087"},{"issue":"1","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"S2037","DOI":"10.1016\/S0167-8140(25)01513-0","article-title":"3138 Salvage Stereotactic Body Radiotherapy (SBRT) for Intraprostatic Relapse After Primary Radiotherapy for Prostate Cancer","volume":"206","author":"Cerrolaza M.","year":"2025","journal-title":"Radiotherapy and Oncology"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1824-4785.25.03565-4"},{"issue":"1","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"S2115","DOI":"10.1016\/S0167-8140(25)03275-X","article-title":"4286 PSMA\u2010Targeted Focal Stereotactic Re\u2010Irradiation in Two Fractions for Recurrent Prostate Cancer Post\u2010 Definitive Radiation Therapy","volume":"206","author":"Hammer L.","year":"2025","journal-title":"Radiotherapy and Oncology"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2025.101900"},{"issue":"1","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"S2015","DOI":"10.1016\/S0167-8140(25)01344-1","article-title":"2880 Re\u2010Irradiation for Isolated Local Recurrence of Prostate Cancer: A Monocentric Experience","volume":"206","author":"Vincini M. G.","year":"2025","journal-title":"Radiotherapy and Oncology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2025.101037"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2020.04.022"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:39:13Z","timestamp":1790753953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":43,"alternative-id":["10.1002\/pros.70233"],"URL":"https:\/\/doi.org\/10.1002\/pros.70233","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,23]]},"assertion":[{"value":"2026-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pros.70233"}}