{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:47:53Z","timestamp":1791805673756,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>PI\u2010RADS 3 lesions on prostate multiparametric MRI (mpMRI) are indeterminate findings with debated management. We evaluated their radiologic evolution on follow\u2010up mpMRI and correlated imaging changes with biopsy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively identified 166 men with at least one PI\u2010RADS 3 lesion on initial mpMRI and at least one follow\u2010up mpMRI without intervening treatment. Lesions were classified at follow\u2010up as regressed (downgraded to PI\u2010RADS\u2009\u2264\u20092), stable (remained PI\u2010RADS 3), or progressed (upgraded to PI\u2010RADS 4\u20135). Lesions were stratified by zonal location. MRI\u2010targeted biopsy results were reviewed when available (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On follow\u2010up, 52% of lesions regressed, 29% remained stable, and 19% progressed. Progression was significantly more common for peripheral\u2010zone lesions (25%) than transition\u2010zone lesions (6%); no central\u2010zone lesions progressed. Of the biopsied lesions, most yielded benign or low\u2010grade pathology: 44% were benign, 47% were ISUP 1, 6% had high\u2010grade PIN or ASAP, and only 3% harbored clinically significant prostate cancer (csPCa; ISUP\u2009\u2265\u20092). Both csPCa cases occurred in lesions that had progressed radiologically. Lesions with imaging progression were significantly more likely to yield cancer on initial or follow\u2010up biopsy than stable\/regressed lesions (83% vs 40%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world cohort, most PI\u2010RADS 3 lesions remained indolent: over half regressed, and 19% progressed. Biopsied lesions had a very low rate of csPCa (3%). These results suggest that surveillance with interval MRI rather than immediate biopsy may be a safe strategy for selected men with PI\u2010RADS 3 lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70240","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:15:36Z","timestamp":1787681736000},"page":"1500-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural History of PI\u2010RADS 3 Lesions on Serial Prostate mpMRI"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-6536","authenticated-orcid":false,"given":"Tomer","family":"Bashi","sequence":"first","affiliation":[{"name":"Department of Urology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"Gray Faculty of Medicine Tel Aviv University Tel Aviv\u2010Yafo 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