{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:41:06Z","timestamp":1792521666365,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Management after suspicious multiparametric MRI (mpMRI; PI\u2010RADS\u2009\u2265\u20093) and an initial biopsy negative for clinically significant prostate cancer (csPCa) remains uncertain. We described the frequency of subsequent csPCa detection and explored baseline factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc longitudinal analysis of MULTIPROS trial data included 153 men with PI\u2010RADS\u2009\u2265\u20093 lesions and no csPCa detected on baseline transrectal systematic biopsy, with or without targeted biopsy. Participants contributed follow\u2010up from the date of the initial mpMRI until csPCa detection or their last available clinical follow\u2010up, with records reviewed through May 2025. Follow\u2010up was not protocol\u2010mandated, and repeat biopsy was guided by clinical findings. The primary outcome was time to histological csPCa detection. Kaplan\u2013Meier and multivariable logistic regression analyses were exploratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median observed time to csPCa detection or censoring of 64 months, csPCa was detected in 37\/153 men (24.2%). Of these, 28\/37 (75.7%) were detected within 6 months, and the median time to detection was 3 months. This early clustering was compatible with possible baseline sampling limitations, although timing alone could not establish this mechanism. Overall, 84\/153 men underwent repeat biopsy and 69\/153 did not; 69\/116 men without detected csPCa lacked repeat histological confirmation. The between\u2010group Kaplan\u2013Meier comparison was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.210) and was difficult to interpret because repeat\u2010biopsy rates differed. Transition\u2010zone location, anterior fibromuscular stroma location, and atypical small acinar proliferation were associated with detection. The hypothesis\u2010generating model had moderate apparent discrimination (AUC 0.756) but low sensitivity at a 0.50 threshold (24.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most detections occurred early, a pattern compatible with possible baseline sampling limitations, although the biological timing of disease onset cannot be established from these data. Selective follow\u2010up limits the interpretation of the detection proportion and between\u2010group comparison. The identified associations require external validation, and the model should not be used clinically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70264","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:32:22Z","timestamp":1792521142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subsequent Detection of Clinically Significant Prostate Cancer After Suspicious MRI and an Initial Biopsy Negative for csPCa: A Longitudinal Subgroup Analysis of the MULTIPROS Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6829-3310","authenticated-orcid":false,"given":"Wafa D.","family":"Aloufi","sequence":"first","affiliation":[{"name":"Division of Imaging Sciences and Technology, School of Medicine University of Dundee, Ninewells Hospital Dundee UK"},{"name":"Department of Radiological Sciences, College of Applied Medical Sciences Taif University Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-9646","authenticated-orcid":false,"given":"Magdalena","family":"Szewczyk\u2010Bieda","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Ninewells Hospital and Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-5195","authenticated-orcid":false,"given":"Ghulam","family":"Nabi","sequence":"additional","affiliation":[{"name":"Division of Imaging Sciences and Technology, School of Medicine University of Dundee, Ninewells Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Population Health and Genomics, School of Medicine University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-7613","authenticated-orcid":false,"given":"Yilong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Science and Engineering University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5714-4863","authenticated-orcid":false,"given":"Cheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Imaging Sciences and Technology, School of Medicine University of Dundee, Ninewells Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-9701","authenticated-orcid":false,"given":"Luigi","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Gastroenterology, School of Medicine University of Dundee, Ninewells Hospital Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17030458"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.06.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.10.140"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221428"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18926"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.26569"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184543"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2337-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00417-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.12.004"},{"key":"e_1_2_10_15_1","unstructured":"National Institute for Health and Care Excellence \u201cProstate Cancer: Diagnosis and Management\u201d NICE Guideline NG131 Published May 9 2019 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